我国近海养殖环境及生物体中有机磷阻燃剂研究进展
Organophosphate Esters in Offshore Aquaculture Environment and Organisms in China: A Review
-
摘要: 有机磷酸酯(organophosphate esters, OPEs)的大量应用使其在多种环境介质以及生物体内被不断检出,其对生态环境和生物体的威胁越来越引起人们的关注。随着经济和社会的发展,我国的生态环境尤其是近岸海洋遭受到了大量有害物质的污染,这将对生态及养殖环境健康和水产品安全产生不利影响。本文对有机磷酸酯在我国近海养殖区域水生生态系统(海水、沉积物及生物)中的残留状况、生物富集特征、毒理信息、迁移转化、生态风险以及健康风险进行了总结和分析。我国近海养殖区域已普遍遭受到OPEs不同程度的污染,OPEs的生物毒性效应以及生物富集作用也被证实,但考虑到生态环境的复杂性和多样性,以及生物体内存在的多种生物化学反应,OPEs在环境及生物中的赋存状况和污染特征,以及生物富集和迁移转化的相关影响因素和机制仍值得关注。本文最后对目前OPEs的相关研究存在的问题和不足进行了分析并提出了研究展望,以期对OPEs的综合研究提供参考和见解。Abstract: Organophosphate esters (OPEs) have been continuously detected in various environmental media and organisms because of their large number of applications, and its threat to the environment and organisms has attracted much attention. China’s ecological environment, especially the coastal ocean, has been polluted by a large number of harmful substances. With the development of China’s economy, it deteriorates the ecological environment, the health of breeding environment, and the safety of aquatic products. The residues, bio-enrichment characteristics, toxicological information, migration, and transformation, and ecological and health risks of organophosphate esters in aquatic ecosystems (seawater, sediments, and organisms) in offshore aquaculture areas in China were summarized and analyzed in this paper. China’s offshore aquaculture areas have been generally polluted by OPEs to varying degrees, and the biological toxicity and bioaccumulation of OPEs have been confirmed. However, considering the complexity and diversity of the ecological environment and the variety of biochemical reactions in organisms, the migration and transformation process of OPEs in the environment and organisms need to be evaluated. The problems and deficiencies in the current related research of OPEs were analyzed, and the research prospect was introduced to provide reference and opinions for the comprehensive research of OPEs.
-
Key words:
- organophosphate ester /
- pollution /
- toxicity effect /
- ecological risk /
- health risk
-
-
van der Veen I, de Boer J. Phosphorus flame retardants: Properties, production, environmental occurrence, toxicity and analysis[J]. Chemosphere, 2012, 88(10): 1119-1153 Chen M H, Ma W L. A review on the occurrence of organophosphate flame retardants in the aquatic environment in China and implications for risk assessment[J]. Science of the Total Environment, 2021, 783: 147064 Li Y Y, Lin T, Hu L M, et al. Time trends of polybrominated diphenyl ethers in East China Seas: Response to the booming of PBDE pollution industry in China[J]. Environment International, 2016, 92-93: 507-514 张月. 国内外阻燃剂市场分析[J]. 精细与专用化学品, 2014, 22(8): 20-24 Zhang Y. Global market analysis of flame retardant[J]. Fine and Specialty Chemicals, 2014, 22(8): 20-24(in Chinese)
欧育湘. 我国有机磷阻燃剂产业的分析与展望[J]. 化工进展, 2011, 30(1): 210-215 Ou Y X. Developments of organic phosphorus flame retardant industry in China[J]. Chemical Industry and Engineering Progress, 2011, 30(1): 210-215(in Chinese)
Bollmann U E, Möller A, Xie Z Y, et al. Occurrence and fate of organophosphorus flame retardants and plasticizers in coastal and marine surface waters[J]. Water Research, 2012, 46(2): 531-538 Ali N, Ali L, Mehdi T, et al. Levels and profiles of organochlorines and flame retardants in car and house dust from Kuwait and Pakistan: Implication for human exposure via dust ingestion[J]. Environment International, 2013, 55: 62-70 Giulivo M, Capri E, Kalogianni E, et al. Occurrence of halogenated and organophosphate flame retardants in sediment and fish samples from three European River Basins[J]. The Science of the Total Environment, 2017, 586: 782-791 Möller A, Xie Z Y, Caba A, et al. Organophosphorus flame retardants and plasticizers in the atmosphere of the North Sea[J]. Environmental Pollution, 2011, 159(12): 3660-3665 Pantelaki I, Voutsa D. Occurrence, analysis and risk assessment of organophosphate esters (OPEs) in biota: A review[J]. Marine Pollution Bulletin, 2020, 160: 111547 Hou R, Xu Y P, Wang Z J. Review of OPFRs in animals and humans: Absorption, bioaccumulation, metabolism, and internal exposure research[J]. Chemosphere, 2016, 153: 78-90 Wei G L, Li D Q, Zhuo M N, et al. Organophosphorus flame retardants and plasticizers: Sources, occurrence, toxicity and human exposure[J]. Environmental Pollution, 2015, 196: 29-46 Dishaw L V, Powers C M, Ryde I T, et al. Is the PentaBDE replacement, tris (1, 3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells[J]. Toxicology and Applied Pharmacology, 2011, 256(3): 281-289 刘艳芬, 张士华, 左明, 等. 东营市近海水产养殖现状及可持续利用对策[J]. 中国渔业经济, 2020, 38(5): 109-115 Liu Y F, Zhang S H, Zuo M, et al. Current situation and suggestions to sustainable development of the aquaculture shallow beach in Dongying City[J]. Chinese Fisheries Economics, 2020, 38(5): 109-115(in Chinese)
Zhang L, Lu L, Zhu W J, et al. Organophosphorus flame retardants (OPFRs) in the seawater and sediments of the Qinzhou Bay, Northern Beibu Gulf: Occurrence, distribution, and ecological risks[J]. Marine Pollution Bulletin, 2021, 168: 112368 Zhang R J, Yu K F, Li A, et al. Occurrence, phase distribution, and bioaccumulation of organophosphate esters (OPEs) in mariculture farms of the Beibu Gulf, China: A health risk assessment through seafood consumption[J]. Environmental Pollution, 2020, 263(Pt B): 114426 Wang R M, Tang J H, Xie Z Y, et al. Occurrence and spatial distribution of organophosphate ester flame retardants and plasticizers in 40 rivers draining into the Bohai Sea, North China[J]. Environmental Pollution, 2015, 198: 172-178 Zhong M Y, Tang J H, Mi L J, et al. Occurrence and spatial distribution of organophosphorus flame retardants and plasticizers in the Bohai and Yellow Seas, China[J]. Marine Pollution Bulletin, 2017, 121(1-2): 331-338 Lai N L S, Kwok K Y, Wang X H, et al. Assessment of organophosphorus flame retardants and plasticizers in aquatic environments of China (Pearl River Delta, South China Sea, Yellow River Estuary) and Japan (Tokyo Bay)[J]. Journal of Hazardous Materials, 2019, 371: 288-294 Aznar-Alemany Ò, Aminot Y, Vilà-Cano J, et al. Halogenated and organophosphorus flame retardants in European aquaculture samples[J]. The Science of the Total Environment, 2018, 612: 492-500 Liu Y H, Song N H, Guo R X, et al. Occurrence and partitioning behavior of organophosphate esters in surface water and sediment of a shallow Chinese freshwater lake (Taihu Lake): Implication for eco-toxicity risk[J]. Chemosphere, 2018, 202: 255-263 Shi Y L, Gao L H, Li W H, et al. Occurrence, distribution and seasonal variation of organophosphate flame retardants and plasticizers in urban surface water in Beijing, China[J]. Environmental Pollution, 2016, 209: 1-10 Sutton R, Chen D, Sun J, et al. Characterization of brominated, chlorinated, and phosphate flame retardants in San Francisco Bay, an urban estuary[J]. The Science of the Total Environment, 2019, 652: 212-223 Chen M Q, Gan Z W, Qu B, et al. Temporal and seasonal variation and ecological risk evaluation of flame retardants in seawater and sediments from Bohai Bay near Tianjin, China during 2014 to 2017[J]. Marine Pollution Bulletin, 2019, 146: 874-883 Wang Y, Wu X W, Zhang Q N, et al. Organophosphate esters in sediment cores from coastal Laizhou Bay of the Bohai Sea, China[J]. The Science of the Total Environment, 2017, 607-608: 103-108 Zeng X Y, Xu L, Liu J, et al. Occurrence and distribution of organophosphorus flame retardants/plasticizers and synthetic musks in sediments from source water in the Pearl River Delta, China[J]. Environmental Toxicology and Chemistry, 2018, 37(4): 975-982 Wang X, Zhu Q Q, Yan X T, et al. A review of organophosphate flame retardants and plasticizers in the environment: Analysis, occurrence and risk assessment[J]. The Science of the Total Environment, 2020, 731: 139071 Tan X X, Luo X J, Zheng X B, et al. Distribution of organophosphorus flame retardants in sediments from the Pearl River Delta in South China[J]. The Science of the Total Environment, 2016, 544: 77-84 Ma Y X, Xie Z Y, Lohmann R, et al. Organophosphate ester flame retardants and plasticizers in ocean sediments from the North Pacific to the Arctic Ocean[J]. Environmental Science & Technology, 2017, 51(7): 3809-3815 Brandsma S H, Leonards P E, Leslie H A, et al. Tracing organophosphorus and brominated flame retardants and plasticizers in an estuarine food web[J]. The Science of the Total Environment, 2015, 505: 22-31 Zhao H Q, Zhao F R, Liu J X, et al. Trophic transfer of organophosphorus flame retardants in a lake food web[J]. Environmental Pollution, 2018, 242(Pt B): 1887-1893 Fu J, Fu K H, Gao K, et al. Occurrence and trophic magnification of organophosphate esters in an Antarctic ecosystem: Insights into the shift from legacy to emerging pollutants[J]. Journal of Hazardous Materials, 2020, 396: 122742 Wang X L, Zhong W J, Xiao B W, et al. Bioavailability and biomagnification of organophosphate esters in the food web of Taihu Lake, China: Impacts of chemical properties and metabolism[J]. Environment International, 2019, 125: 25-32 Bekele T G, Zhao H X, Wang Q Z, et al. Bioaccumulation and trophic transfer of emerging organophosphate flame retardants in the marine food webs of Laizhou Bay, North China[J]. Environmental Science & Technology, 2019, 53(22): 13417-13426 Ding Y, Han M W, Wu Z Q, et al. Bioaccumulation and trophic transfer of organophosphate esters in tropical marine food web, South China Sea[J]. Environment International, 2020, 143: 105919 李雨琦, 李玮, 张蓉蓉, 等. QuEChERS-气相色谱串联质谱法测定海水鱼体中有机磷阻燃剂[J]. 分析试验室, 2020, 39(8): 869-874 Li Y Q, Li W, Zhang R R, et al. Determination of organophosphorus flame retardants in marine fish by QuEChERS-gas chromatography tandem mass spectrometry[J]. Chinese Journal of Analysis Laboratory, 2020, 39(8): 869-874(in Chinese)
Zhang Y, Zheng X B, Wei L F, et al. The distribution and accumulation of phosphate flame retardants (PFRs) in water environment[J]. The Science of the Total Environment, 2018, 630: 164-170 Sala B, Giménez J, Fernández-Arribas J, et al. Organophosphate ester plasticizers in edible fish from the Mediterranean Sea: Marine pollution and human exposure[J]. Environmental Pollution, 2022, 292(Pt B): 118377 Kim J W, Isobe T, Chang K H, et al. Levels and distribution of organophosphorus flame retardants and plasticizers in fishes from Manila Bay, the Philippines[J]. Environmental Pollution, 2011, 159(12): 3653-3659 Aznar-Alemany Ò, Sala B, Plön S, et al. Halogenated and organophosphorus flame retardants in cetaceans from the southwestern Indian Ocean[J]. Chemosphere, 2019, 226: 791-799 Garcia-Garin O, Sala B, Aguilar A, et al. Organophosphate contaminants in North Atlantic fin whales[J]. The Science of the Total Environment, 2020, 721: 137768 张丽, 张少峰, 于硕. 水环境中的有机磷阻燃剂及其生物富集和生物转化研究进展[J]. 生态毒理学报, 2021, 16(3): 78-94 Zhang L, Zhang S F, Yu S. Organophosphorus flame retardants in aquatic environment: A review on occurrence, bioaccumulation and metabolism[J]. Asian Journal of Ecotoxicology, 2021, 16(3): 78-94(in Chinese)
Wang G W, Shi H H, Du Z K, et al. Bioaccumulation mechanism of organophosphate esters in adult zebrafish (Danio rerio)[J]. Environmental Pollution, 2017, 229: 177-187 Arukwe A, Carteny C C, Eggen T, et al. Novel aspects of uptake patterns, metabolite formation and toxicological responses in Salmon exposed to the organophosphate esters-tris(2-butoxyethyl)- and tris(2-chloroethyl) phosphate[J]. Aquatic Toxicology, 2018, 196: 146-153 Tang B, Poma G, Bastiaensen M, et al. Bioconcentration and biotransformation of organophosphorus flame retardants (PFRs) in common carp (Cyprinus carpio)[J]. Environment International, 2019, 126: 512-522 Choo G, Cho H S, Park K, et al. Tissue-specific distribution and bioaccumulation potential of organophosphate flame retardants in crucian carp[J]. Environmental Pollution, 2018, 239: 161-168 罗孝俊, 麦碧娴. 新型持久性有机污染物的生物富集[M]. 北京: 科学出版社, 2017: 3-4 Liu Y E, Luo X J, Zapata Corella P, et al. Organophosphorus flame retardants in a typical freshwater food web: Bioaccumulation factors, tissue distribution, and trophic transfer[J]. Environmental Pollution, 2019, 255(Pt 2): 113286 刘佳. 有机磷酸酯阻燃剂污染现状及降解过程研究进展[J]. 应用化工, 2018, 47(12): 2705-2710 , 2714 Liu J. Review of contamination status and degradation processes of organophosphate ester (OPE) flame retardants[J]. Applied Chemical Industry, 2018, 47(12): 2705-2710, 2714(in Chinese)
Su G Y, Letcher R J, Yu H X. Organophosphate flame retardants and plasticizers in aqueous solution: PH-dependent hydrolysis, kinetics, and pathways[J]. Environmental Science & Technology, 2016, 50(15): 8103-8111 Fang Y D, Kim E, Strathmann T J. Mineral- and base-catalyzed hydrolysis of organophosphate flame retardants: Potential major fate-controlling sink in soil and aquatic environments[J]. Environmental Science & Technology, 2018, 52(4): 1997-2006 Cristale J, Dantas R F, Luca A D, et al. Role of oxygen and DOM in sunlight induced photodegradation of organophosphorous flame retardants in river water[J]. Journal of Hazardous Materials, 2017, 323(Pt A): 242-249 Sun S B, Jiang J Q, Zhao H X, et al. Photochemical reaction of tricresyl phosphate (TCP) in aqueous solution: Influencing factors and photolysis products[J]. Chemosphere, 2020, 241: 124971 艾锐, 阮新潮, 曾庆福. UV/H2O2降解水体中磷酸三(1,3-二氯-2-丙基)酯的研究[J]. 湖北农业科学, 2014, 53(5): 1044-1047 Ai R, Ruan X C, Zeng Q F. Photodegradation of tris(1,3-dichloro-2-propyl) phosphate in aqueous solution by UV/H2O2[J]. Hubei Agricultural Sciences, 2014, 53(5): 1044-1047(in Chinese)
Takahashi S, Kawashima K, Kawasaki M, et al. Enrichment and characterization of chlorinated organophosphate ester-degrading mixed bacterial cultures[J]. Journal of Bioscience and Bioengineering, 2008, 106(1): 27-32 Takahashi S, Satake I, Konuma I, et al. Isolation and identification of persistent chlorinated organophosphorus flame retardant-degrading bacteria[J]. Applied and Environmental Microbiology, 2010, 76(15): 5292-5296 Takahashi S, Obana Y, Okada S, et al. Complete detoxification of tris(1,3-dichloro-2-propyl) phosphate by mixed two bacteria, Sphingobium sp. strain TCM1 and Arthrobacter sp. strain PY1[J]. Journal of Bioscience and Bioengineering, 2012, 113(1): 79-83 Takahashi S, Miura K, Abe K, et al. Complete detoxification of tris(2-chloroethyl) phosphate by two bacterial strains: Sphingobium sp. strain TCM1 and Xanthobacter autotrophicus strain GJ10[J]. Journal of Bioscience and Bioengineering, 2012, 114(3): 306-311 Berne C, Montjarret B, Guountti Y, et al. Tributyl phosphate degradation by Serratia odorifera[J]. Biotechnology Letters, 2004, 26(8): 681-686 Kulkarni S V, Markad V L, Melo J S, et al. Biodegradation of tributyl phosphate using Klebsiella pneumoniae sp. S3[J]. Applied Microbiology and Biotechnology, 2014, 98(2): 919-929 Wei K, Yin H, Peng H, et al. Bioremediation of triphenyl phosphate in river water microcosms: Proteome alteration of Brevibacillus brevis and cytotoxicity assessments[J]. The Science of the Total Environment, 2019, 649: 563-570 Vila-Costa M, Sebastián M, Pizarro M, et al. Microbial consumption of organophosphate esters in seawater under phosphorus limited conditions[J]. Scientific Reports, 2019, 9(1): 233 Wang G W, Du Z K, Chen H Y, et al. Tissue-specific accumulation, depuration, and transformation of triphenyl phosphate (TPHP) in adult zebrafish (Danio rerio)[J]. Environmental Science & Technology, 2016, 50(24): 13555-13564 Hou R, Liu C, Gao X Z, et al. Accumulation and distribution of organophosphate flame retardants (PFRs) and their di-alkyl phosphates (DAPs) metabolites in different freshwater fish from locations around Beijing, China[J]. Environmental Pollution, 2017, 229: 548-556 Su G Y, Crump D, Letcher R J, et al. Rapid in vitro metabolism of the flame retardant triphenyl phosphate and effects on cytotoxicity and mRNA expression in chicken embryonic hepatocytes[J]. Environmental Science & Technology, 2014, 48(22): 13511-13519 Sasaki K, Suzuki T, Takeda M, et al. Metabolism of phosphoric acid triesters by rat liver homogenate[J]. Bulletin of Environmental Contamination and Toxicology, 1984, 33(3): 281-288 Van den Eede N, Maho W, Erratico C, et al. First insights in the metabolism of phosphate flame retardants and plasticizers using human liver fractions[J]. Toxicology Letters, 2013, 223(1): 9-15 Wang L, Huang X L, Lim D J, et al. Uptake and toxic effects of triphenyl phosphate on freshwater microalgae Chlorella vulgaris and Scenedesmus obliquus: Insights from untargeted metabolomics[J]. The Science of the Total Environment, 2019, 650(Pt 1): 1239-1249 Liu Q, Tang X X, Jian X Y, et al. Toxic effect and mechanism of tris (1,3-dichloro-2-propyl)phosphate (TDCPP) on the marine alga Phaeodactylum tricornutum[J]. Chemosphere, 2020, 252: 126467 Wang L, Huang X L, Laserna A K C, et al. Metabolomics reveals that tris(1,3-dichloro-2-propyl)phosphate (TDCPP) causes disruption of membrane lipids in microalga Scenedesmus obliquus[J]. The Science of the Total Environment, 2020, 708: 134498 Liu Q, Tang X X, Wang Y, et al. ROS changes are responsible for tributyl phosphate (TBP)-induced toxicity in the alga Phaeodactylum tricornutum[J]. Aquatic Toxicology, 2019, 208: 168-178 Song H, Fan X J, Liu G F, et al. Inhibitory effects of tributyl phosphate on algal growth, photosynthesis, and fatty acid synthesis in the marine diatom Phaeodactylum tricornutum[J]. Environmental Science and Pollution Research International, 2016, 23(23): 24009-24018 Verbruggen E M J, Rila J P, Traas T P, et al. Environmental risk limits for several phosphate esters, with possible application as flame retardant. RIVM report 601501024[R]. Bilthoven: RIVM, 2006: 10-50 Giraudo M, Dubé M, Lépine M, et al. Multigenerational effects evaluation of the flame retardant tris(2-butoxyethyl) phosphate (TBOEP) using Daphnia magna[J]. Aquatic Toxicology, 2017, 190: 142-149 Yuan S L, Li H, Dang Y, et al. Effects of triphenyl phosphate on growth, reproduction and transcription of genes of Daphnia magna[J]. Aquatic Toxicology, 2018, 195: 58-66 Li H, Su G Y, Zou M, et al. Effects of tris(1,3-dichloro-2-propyl) phosphate on growth, reproduction, and gene transcription of Daphnia magna at environmentally relevant concentrations[J]. Environmental Science & Technology, 2015, 49(21): 12975-12983 皮天星, 蔡磊明, 蒋金花, 等. 新型阻燃剂TCPP对斑马鱼的毒性研究[J]. 生态毒理学报, 2016, 11(2): 247-256 Pi T X, Cai L M, Jiang J H, et al. Toxicity effects of a new flame retardant tris(2-chloroisopropyl) phosphate to zebrafish (Danio rerio)[J]. Asian Journal of Ecotoxicology, 2016, 11(2): 247-256(in Chinese)
Wang Q W, Lai N L S, Wang X F, et al. Bioconcentration and transfer of the organophorous flame retardant 1,3-dichloro-2-propyl phosphate causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish larvae[J]. Environmental Science & Technology, 2015, 49(8): 5123-5132 Zhang Y K, Yi X E, Huang K, et al. Tris(1,3-dichloro-2-propyl)phosphate reduces growth hormone expression via binding to growth hormone releasing hormone receptors and inhibits the growth of crucian carp[J]. Environmental Science & Technology, 2021, 55(12): 8108-8118 Li Y, Wang C, Zhao F R, et al. Environmentally relevant concentrations of the organophosphorus flame retardant triphenyl phosphate impaired testicular development and reproductive behaviors in Japanese medaka (Oryzias latipes)[J]. Environmental Science & Technology Letters, 2018, 5(11): 649-654 Hong X S, Chen R, Hou R, et al. Triphenyl phosphate (TPHP)-induced neurotoxicity in adult male Chinese rare minnows (Gobiocypris rarus)[J]. Environmental Science & Technology, 2018, 52(20): 11895-11903 Wang L Y, Gu Y Y, Zhang Z M, et al. Contaminant occurrence, mobility and ecological risk assessment of phthalate esters in the sediment-water system of the Hangzhou Bay[J]. Science of the Total Environment, 2021, 770: 144705 Beyer J, Green N W, Brooks S, et al. Blue mussels (Mytilus edulis spp.) as sentinel organisms in coastal pollution monitoring: A review[J]. Marine Environmental Research, 2017, 130: 338-365 Sánchez-Marín P, Vidal-Liñán L, Fernández-González L E, et al. Proteomic analysis and biochemical alterations in marine mussel gills after exposure to the organophosphate flame retardant TDCPP[J]. Aquatic Toxicology, 2021, 230: 105688 Wu H F, Zhong M Y, Lu Z, et al. Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis[J]. Environmental Toxicology and Pharmacology, 2018, 61: 102-106 Li D D, Wang P F, Wang X, et al. Elucidating multilevel toxicity response differences between tris(1,3-dichloro-2-propyl) phosphate and its primary metabolite in Corbicula fluminea[J]. The Science of the Total Environment, 2020, 749: 142049 Yan S H, Wu H M, Qin J H, et al. Halogen-free organophosphorus flame retardants caused oxidative stress and multixenobiotic resistance in Asian freshwater clams (Corbicula fluminea)[J]. Environmental Pollution, 2017, 225: 559-568 Yan S H, Wang Q, Yang L H, et al. Comparison of the toxicity effects of tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with tributyl phosphate (TNBP) reveals the mechanism of the apoptosis pathway in Asian freshwater clams (Corbicula fluminea)[J]. Environmental Science & Technology, 2020, 54(11): 6850-6858 Kim S, Jung J, Lee I, et al. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines[J]. Aquatic Toxicology, 2015, 160: 188-196 Lin K D. Joint acute toxicity of tributyl phosphate and triphenyl phosphate to Daphnia magna[J]. Environmental Chemistry Letters, 2009, 7(4): 309-312 Paluselli A, Kim S K. Horizontal and vertical distribution of phthalates acid ester (PAEs) in seawater and sediment of East China Sea and Korean South Sea: Traces of plastic debris?[J]. Marine Pollution Bulletin, 2020, 151: 110831 Wu T T, Mao L L, Liu X T, et al. Seasonal occurrence, allocation and ecological risk of organophosphate esters in a typical urbanized semi-closed bay[J]. Environmental Pollution, 2021, 290: 118074 Fang L D, Liu A F, Zheng M G, et al. Occurrence and distribution of organophosphate flame retardants in seawater and sediment from coastal areas of the East China and Yellow Seas[J]. Environmental Pollution, 2022, 302: 119017 Luo Q, Wu Z P, Wang C C, et al. Seasonal variation, source identification, and risk assessment of organophosphate ester flame retardants and plasticizers in surficial sediments from Liao River Estuary wetland, China[J]. Marine Pollution Bulletin, 2021, 173(Pt A): 112947 Bekele T G, Zhao H X, Wang Q Z. Tissue distribution and bioaccumulation of organophosphate esters in wild marine fish from Laizhou Bay, North China: Implications of human exposure via fish consumption[J]. Journal of Hazardous Materials, 2021, 401: 123410 Ding J J, Deng T Q, Xu M M, et al. Residuals of organophosphate esters in foodstuffs and implication for human exposure[J]. Environmental Pollution, 2018, 233: 986-991 Zhao L M, Jian K, Su H J, et al. Organophosphate esters (OPEs) in Chinese foodstuffs: Dietary intake estimation via a market basket method, and suspect screening using high-resolution mass spectrometry[J]. Environment International, 2019, 128: 343-352 Wang X W, He Y Q, Lin L, et al. Application of fully automatic hollow fiber liquid phase microextraction to assess the distribution of organophosphate esters in the Pearl River Estuaries[J]. The Science of the Total Environment, 2014, 470-471: 263-269 Niu Z G, Zhang Z Z, Li J F, et al. Threats of organophosphate esters (OPEs) in surface water to ecological system in Haihe River of China based on species sensitivity distribution model and assessment factor model[J]. Environmental Science and Pollution Research International, 2019, 26(11): 10854-10866 Yan X J, He H, Peng Y, et al. Determination of organophosphorus flame retardants in surface water by solid phase extraction coupled with gas chromatography-mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2012, 40(11): 1693-1697 Sühring R, Diamond M L, Bernstein S, et al. Organophosphate esters in the Canadian Arctic Ocean[J]. Environmental Science & Technology, 2021, 55(1): 304-312 Gao X Z, Lin Y Y, Li J Y, et al. Spatial pattern analysis reveals multiple sources of organophosphorus flame retardants in coastal waters[J]. Journal of Hazardous Materials, 2021, 417: 125882 Dou W K, Zhang Z M, Huang W, et al. Contaminant occurrence, spatiotemporal variation, and ecological risk of organophosphorus flame retardants (OPFRs) in Hangzhou Bay and East China Sea ecosystem[J]. Chemosphere, 2022, 303: 135032 Zhang Z M, Dou W K, Zhang X Q, et al. Organophosphate esters in the mariculture ecosystem: Environmental occurrence and risk assessments[J]. Journal of Hazardous Materials, 2022, 436: 129219 Li J, Xie Z Y, Mi W Y, et al. Organophosphate esters in air, snow, and seawater in the North Atlantic and the Arctic[J]. Environmental Science & Technology, 2017, 51(12): 6887-6896 Ma Y Q, Cui K Y, Zeng F, et al. Microwave-assisted extraction combined with gel permeation chromatography and silica gel cleanup followed by gas chromatography-mass spectrometry for the determination of organophosphorus flame retardants and plasticizers in biological samples[J]. Analytica Chimica Acta, 2013, 786: 47-53 Castro Ó, Pocurull E, Borrull F. Determination of organophosphate ester flame retardants and plasticisers in fish samples by QuEChERs followed by gas chromatography-tandem mass spectrometry. Exposure and risk assessment through fish consumption[J]. Journal of Chromatography A, 2020, 1626: 461356 高小中, 许宜平, 王子健. 有机磷酸酯阻燃剂的环境暴露与迁移转化研究进展[J]. 生态毒理学报, 2015, 10(2): 56-68 Gao X Z, Xu Y P, Wang Z J. Progress in environment exposure, transport and transform of organophosphorus flame retardants[J]. Asian Journal of Ecotoxicology, 2015, 10(2): 56-68(in Chinese)
Jurgens S S, Helmus R, Waaijers S L, et al. Mineralisation and primary biodegradation of aromatic organophosphorus flame retardants in activated sludge[J]. Chemosphere, 2014, 111: 238-242 Krivoshiev B V, Dardenne F, Blust R, et al. Elucidating toxicological mechanisms of current flame retardants using a bacterial gene profiling assay[J]. Toxicology in Vitro, 2015, 29(8): 2124-2132 Li F, Cao L L, Li X H, et al. Affinities of organophosphate flame retardants to tumor suppressor gene p53: An integrated in vitro and in silico study[J]. Toxicology Letters, 2015, 232(2): 533-541 姜丹, 周建国, 李娜, 等. 有机磷酸酯对青海弧菌Q67毒性的构效关系[J]. 生态毒理学报, 2014, 9(1): 71-80 Jiang D, Zhou J G, Li N, et al. Quantitative structure-activity relationships between acute toxicity of organophosphates and Vibrio qinghaiensis sp.-Q67[J]. Asian Journal of Ecotoxicology, 2014, 9(1): 71-80(in Chinese)
Cristale J, García Vázquez A, Barata C, et al. Priority and emerging flame retardants in rivers: Occurrence in water and sediment, Daphnia magna toxicity and risk assessment[J]. Environment International, 2013, 59: 232-243 Li R W, Wang H Q, Mi C, et al. The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae[J]. Chemosphere, 2019, 220: 811-817 Wang C Q, Chen Z H, Lu Y M, et al. Neurotoxicity and related mechanisms of flame retardant TCEP exposure in mice[J]. Toxicology Mechanisms and Methods, 2020, 30(7): 490-496 Yu X L, Yin H, Peng H, et al. OPFRs and BFRs induced A549 cell apoptosis by caspase-dependent mitochondrial pathway[J]. Chemosphere, 2019, 221: 693-702 Liu X S, Ji K, Choi K. Endocrine disruption potentials of organophosphate flame retardants and related mechanisms in H295R and MVLN cell lines and in zebrafish[J]. Aquatic Toxicology, 2012, 114-115: 173-181 Zhang J K, Abdallah M A, Williams T D, et al. Gene expression and metabolic responses of HepG2/C3A cells exposed to flame retardants and dust extracts at concentrations relevant to indoor environmental exposures[J]. Chemosphere, 2016, 144: 1996-2003 Liu C S, Wang Q W, Liang K, et al. Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae[J]. Aquatic Toxicology, 2013, 128-129: 147-157 Zhu Y, Ma X F, Su G Y, et al. Environmentally relevant concentrations of the flame retardant tris(1,3-dichloro-2-propyl) phosphate inhibit growth of female zebrafish and decrease fecundity[J]. Environmental Science & Technology, 2015, 49(24): 14579-14587 Yuan L L, Li J S, Zha J M, et al. Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus)[J]. Environmental Pollution, 2016, 208: 670-677 Wang Q W, Lam J C, Man Y C, et al. Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish[J]. Aquatic Toxicology, 2015, 158: 108-115 Alzualde A, Behl M, Sipes N S, et al. Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward human relevance[J]. Neurotoxicology and Teratology, 2018, 70: 40-50 Dasgupta S, Vliet S M F, Cheng V, et al. Complex interplay among nuclear receptor ligands, cytosine methylation, and the metabolome in driving tris(1,3-dichloro-2-propyl)phosphate-induced epiboly defects in zebrafish[J]. Environmental Science & Technology, 2019, 53(17): 10497-10505 Wang Q W, Liang K, Liu J F, et al. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis[J]. Aquatic Toxicology, 2013, 126: 207-213 Li Y, Fu Y R, Hu K Q, et al. Positive correlation between human exposure to organophosphate esters and gastrointestinal cancer in patients from Wuhan, China[J]. Ecotoxicology and Environmental Safety, 2020, 196: 110548 Kwon B, Shin H, Moon H B, et al. Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)[J]. Environmental Pollution, 2016, 214: 568-574 Giraudo M, Douville M, Houde M. Chronic toxicity evaluation of the flame retardant tris (2-butoxyethyl) phosphate (TBOEP) using Daphnia magna transcriptomic response[J]. Chemosphere, 2015, 132: 159-165 Hong X S, Chen R, Yuan L L, et al. Global microRNA and isomiR expression associated with liver metabolism is induced by organophosphorus flame retardant exposure in male Chinese rare minnow (Gobiocypris rarus)[J]. The Science of the Total Environment, 2019, 649: 829-838 Pang L, Liu J F, Yin Y G, et al. Evaluating the sorption of organophosphate esters to different sourced humic acids and its effects on the toxicity to Daphnia magna[J]. Environmental Toxicology and Chemistry, 2013, 32(12): 2755-2761 Du Z K, Zhang Y, Wang G W, et al. TPhP exposure disturbs carbohydrate metabolism, lipid metabolism, and the DNA damage repair system in zebrafish liver[J]. Scientific Reports, 2016, 6: 21827 Li Y, Kang Q Y, Chen R C, et al. 2-ethylhexyl diphenyl phosphate and its hydroxylated metabolites are anti-androgenic and cause adverse reproductive outcomes in male Japanese medaka (Oryzias latipes)[J]. Environmental Science & Technology, 2020, 54(14): 8919-8925 周贵珍, 曾涛, 张利平, 等. 磷酸三邻甲苯酯对母鸡中枢神经组织ATP含量的影响[J]. 环境与职业医学, 2009, 26(1): 20-23 Zhou G Z, Zeng T, Zhang L P, et al. Effects of tri-o-cresyl phosphate (TOCP)on ATP concentration in hen's central nervous tissues[J]. Journal of Environmental & Occupational Medicine, 2009, 26(1): 20-23(in Chinese)
McGee S P, Konstantinov A, Stapleton H M, et al. Aryl phosphate esters within a major PentaBDE replacement product induce cardiotoxicity in developing zebrafish embryos: Potential role of the aryl hydrocarbon receptor[J]. Toxicological Sciences, 2013, 133(1): 144-156 -

计量
- 文章访问数: 1383
- HTML全文浏览数: 1383
- PDF下载数: 92
- 施引文献: 0