水环境中农药类污染物的内分泌干扰效应研究
Endocrine Disrupting Effects of Pesticides in Water Environment
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摘要: 水环境中农药类内分泌干扰物与人类健康密切相关。以水源水中筛查鉴定出的15种农药类污染物为对象，采用化学激活荧光素酶基因表达法(CALUX)，进行了雌激素受体(ER)、雄激素受体(AR)、肾上腺皮质激素受体(GR)激动和拮抗效应筛查。研究结果显示所有测试物均未显示激素受体激动效应，环莠隆具有ER拮抗效应，多效唑、戊唑醇和三环唑表现出AR拮抗效应，阿特拉津、扑草净、三环唑和甲霜灵表现出GR拮抗作用。研究结果为水环境中农药类污染物的风险评估提供支撑。
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关键词:
- 农药 /
- 化学诱导荧光素酶表达基因法 /
- 内分泌干扰物 /
- 综合激素效应
Abstract: Pesticide endocrine disruptors in water environment are closely related to human health. In this study, the chemical activated luciferase gene expression (CALUX) was used to screen the promoting and antagonistic effects of 15 pesticide pollutants identified in source water, including estrogen receptor (ER), androgen receptor (AR) and glucocorticoid receptor (GR). None of the tested substances showed hormonal receptor promoting effect. Cycluron was shown as estrogen receptor antagonistic effect. Paclobutrazol, tebuconazole and tricyclazole were shown as androgen receptor antagonistic effect. Atrazine, prometryn, tricyclazole and metalaxyl were shown as glucocorticoid receptor antagonistic activity. The research results provide support for the risk assessment of pesticide pollutants in water environment. -
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