[1] COX P A, BANACK S A, MURCH S J, et al. Diverse taxa of cyanobacteria produce β-N-methylamino-L-alanine, a neurotoxic amino acid [J]. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(14): 5074-5078. doi: 10.1073/pnas.0501526102
[2] SPENCER P S, NUNN P B, HUGON J, et al. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin [J]. Science, 1987, 237(4814): 517-522. doi: 10.1126/science.3603037
[3] CHERNOFF N, HILL D J, DIGGS D L, et al. A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans [J]. Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 2017, 20(4): 1-47.
[4] MANOLIDI K, TRIANTIS T M, KALOUDIS T, et al. Neurotoxin BMAA and its isomeric amino acids in cyanobacteria and cyanobacteria-based food supplements [J]. Journal of Hazardous Materials, 2019, 365: 346-365. doi: 10.1016/j.jhazmat.2018.10.084
[5] JIAO Y Y, CHEN Q K, CHEN X, et al. Occurrence and transfer of a cyanobacterial neurotoxin β-methylamino-L-alanine within the aquatic food webs of Gonghu Bay (Lake Taihu, China) to evaluate the potential human health risk [J]. Science of the Total Environment, 2014, 468/469: 457-463. doi: 10.1016/j.scitotenv.2013.08.064
[6] RÉVEILLON D, SÉCHET V, HESS P, et al. Systematic detection of BMAA (β-N-methylamino-L-alanine) and DAB (2,4-diaminobutyric acid) in mollusks collected in shellfish production areas along the French coasts [J]. Toxicon, 2016, 110: 35-46. doi: 10.1016/j.toxicon.2015.11.011
[7] SCHNEIDER T, SIMPSON C, DESAI P, et al. Neurotoxicity of isomers of the environmental toxin L-BMAA [J]. Toxicon, 2020, 184: 175-179. doi: 10.1016/j.toxicon.2020.06.014
[8] GALLO-TORRES H E, HEIMER E, SCHEIDL F, et al. The gastrointestinal absorption, tissue distribution, urinary excretion and metabolism of N-(2-aminoethyl)-Glycine (AEG) in the rat [J]. Life Sciences, 1980, 27(24): 2347-2357. doi: 10.1016/0024-3205(80)90504-4
[9] 王超, 邱江兵, 宋甲亮, 等. 不同液相色谱-质谱联用法分析贝类样品中神经毒素β-N-甲氨基-L-丙氨酸的比较 [J]. 中国渔业质量与标准, 2021, 11(1): 34-45. WANG C, QIU J B, SONG J L, et al. A comparative study on the analytical performance of different liquid chromatography coupled with tandem mass spectrometry for neurotoxin β-N-methylamino-L-alanine in mollusks [J]. Chinese Fishery Quality and Standards, 2021, 11(1): 34-45(in Chinese).
[10] HOEFFER C A, KLANN E. mTOR signaling: At the crossroads of plasticity, memory and disease [J]. Trends in Neurosciences, 2010, 33(2): 67-75. doi: 10.1016/j.tins.2009.11.003
[11] CHONG Z Z, SHANG Y C, WANG S H, et al. A critical kinase cascade in neurological disorders: PI 3-K, Akt, and mTOR [J]. Future Neurology, 2012, 7(6): 733-748. doi: 10.2217/fnl.12.72
[12] PAPAPETROPOULOS S. Is there a role for naturally occurring cyanobacterial toxins in neurodegeneration? The beta-N-methylamino-L-alanine (BMAA) paradigm [J]. Neurochemistry International, 2007, 50(7/8): 998-1003.
[13] EMMONS R V, KARAJ E, CUDJOE E, et al. Leveraging multi-mode microextraction and liquid chromatography stationary phases for quantitative analysis of neurotoxin β-N-methylamino-L-alanine and other non-proteinogenic amino acids [J]. Journal Of Chromatography A, 2022, 1685: 463636. doi: 10.1016/j.chroma.2022.463636
[14] PAGLIARA P, DE BENEDETTO G E, FRANCAVILLA M, et al. Bioactive potential of two marine picocyanobacteria belonging to cyanobium and synechococcus genera[J]. Microorganisms, 2021, 9(10):2048.
[15] ZHAO P, QIU J B, LI A F, et al. Matrix effect of diverse biological samples extracted with different extraction ratios on the detection of β-N-methylamino-L-alanine by two common LC-MS/MS analysis methods [J]. Toxins, 2022, 14(6): 387. doi: 10.3390/toxins14060387
[16] ROSÉN J, WESTERBERG E, HELLENÄS K E, et al. A new method for analysis of underivatized free β-methylamino-alanine: Validation and method comparison [J]. Toxicon, 2016, 121: 105-108. doi: 10.1016/j.toxicon.2016.08.021
[17] FAASSEN E J, GILLISSEN F, LÜRLING M. A comparative study on three analytical methods for the determination of the neurotoxin BMAA in cyanobacteria [J]. PLoS One, 2012, 7(5): e36667. doi: 10.1371/journal.pone.0036667
[18] BISHOP S L, MURCH S J. A systematic review of analytical methods for the detection and quantification of β-N-methylamino-L-alanine (BMAA) [J]. Analyst, 2019, 145(1): 13-28.
[19] APARICIO-MURIANA M M, CARMONA-MOLERO R, LARA F J, et al. Multiclass cyanotoxin analysis in reservoir waters: Tandem solid-phase extraction followed by zwitterionic hydrophilic interaction liquid chromatography-mass spectrometry [J]. Talanta, 2022, 237: 122929. doi: 10.1016/j.talanta.2021.122929
[20] VO DUY S, MUNOZ G, DINH Q T, et al. Analysis of the neurotoxin β-N-methylamino-L-alanine (BMAA) and isomers in surface water by FMOC derivatization liquid chromatography high resolution mass spectrometry [J]. PLoS One, 2019, 14(8): e0220698. doi: 10.1371/journal.pone.0220698
[21] METCALF J S, BANACK S A, WESSEL R A, et al. Toxin analysis of freshwater cyanobacterial and marine harmful algal blooms on the west coast of Florida and implications for estuarine environments [J]. Neurotoxicity Research, 2021, 39(1): 27-35. doi: 10.1007/s12640-020-00248-3
[22] MAIN B J, BOWLING L C, PADULA M P, et al. Detection of the suspected neurotoxin β-methylamino-L-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia [J]. Harmful Algae, 2018, 74: 10-18. doi: 10.1016/j.hal.2018.03.004
[23] CHATZIEFTHIMIOU A D, BANACK S A, COX P A. Biocrust-produced cyanotoxins are found vertically in the desert soil profile [J]. Neurotoxicity Research, 2021, 39(1): 42-48. doi: 10.1007/s12640-020-00224-x
[24] BANACK S A. Second laboratory validation of β-N-methylamino-L-alanine, N-(2-aminoethyl)glycine, and 2, 4-diaminobuytric acid by ultra-performance liquid chromatography and tandem mass spectrometry [J]. Neurotoxicity Research, 2021, 39(1): 107-116. doi: 10.1007/s12640-020-00208-x
[25] LI A, HU Y, SONG J, et al. Ubiquity of the neurotoxin β-N-methylamino-L-alanine and its isomers confirmed by two different mass spectrometric methods in diverse marine mollusks [J]. Toxicon, 2018, 151: 129-136. doi: 10.1016/j.toxicon.2018.07.004
[26] GLOVER W B, BAKER T C, MURCH S J, et al. Determination of β-N-methylamino-L-alanine, N-(2-aminoethyl)glycine, and 2,4-diaminobutyric acid in food products containing cyanobacteria by ultra-performance liquid chromatography and tandem mass spectrometry: Single-laboratory validation [J]. Journal of AOAC International, 2015, 98(6): 1559-1565. doi: 10.5740/jaoacint.15-084
[27] BAKER T C, TYMM F J M, MURCH S J. Assessing environmental exposure to β-N-methylamino-L-alanine (BMAA) in complex sample matrices: A comparison of the three most popular LC-MS/MS methods [J]. Neurotoxicity Research, 2018, 33(1): 43-54. doi: 10.1007/s12640-017-9764-3
[28] TYMM F J M, BISHOP S L, MURCH S J. A single laboratory validation for the analysis of underivatized β-N-methylamino-L-alanine (BMAA) [J]. Neurotoxicity Research, 2021, 39(1): 49-71. doi: 10.1007/s12640-019-00137-4
[29] LAGE S, ANNADOTTER H, RASMUSSEN U, et al. Biotransfer of β-N-methylamino-L-alanine (BMAA) in a eutrophicated freshwater lake [J]. Marine Drugs, 2015, 13(3): 1185-1201. doi: 10.3390/md13031185
[30] LAGE S, BURIAN A, RASMUSSEN U, et al. BMAA extraction of cyanobacteria samples: Which method to choose? [J]. Environmental Science and Pollution Research International, 2016, 23(1): 338-350. doi: 10.1007/s11356-015-5266-0
[31] CERVANTES CIANCA R C, BAPTISTA M S, LOPES V R, et al. The non-protein amino acid β-N-methylamino-L-alanine in portuguese cyanobacterial isolates [J]. Amino Acids, 2012, 42(6): 2473-2479. doi: 10.1007/s00726-011-1057-1
[32] CAO Y, HU S Y, GONG T T, et al. Decomposition of β-N-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) during chlorination and consequent disinfection byproducts formation [J]. Water Research, 2019, 159: 365-374. doi: 10.1016/j.watres.2019.05.007
[33] VIOLI J P, MITROVIC S M, COLVILLE A, et al. Prevalence of β-methylamino-L-alanine (BMAA) and its isomers in freshwater cyanobacteria isolated from eastern Australia [J]. Ecotoxicology and Environmental Safety, 2019, 172: 72-81. doi: 10.1016/j.ecoenv.2019.01.046
[34] CHATZIEFTHIMIOU A D, DEITCH E J, GLOVER W B, et al. Analysis of neurotoxic amino acids from marine waters, microbial mats, and seafood destined for human consumption in the Arabian Gulf [J]. Neurotoxicity Research, 2018, 33(1): 143-152. doi: 10.1007/s12640-017-9772-3
[35] 闫博引. 蓝藻神经毒素BMAA在水中赋存状态及氧化降解机制[D]. 哈尔滨: 哈尔滨工业大学, 2020. YAN B Y. Occurrence state and oxidative degragation mechanism of cyanobacterial neurotoxin BMAA in water[D]. Harbin: Harbin Institute of Technology, 2020(in Chinese).
[36] FAASSEN E J, ANTONIOU M G, BEEKMAN-LUKASSEN W, et al. A collaborative evaluation of LC-MS/MS based methods for BMAA analysis: Soluble bound BMAA found to be an important fraction [J]. Marine Drugs, 2016, 14(3): 45. doi: 10.3390/md14030045
[37] LANCE E, ARNICH N, MAIGNIEN T, et al. Occurrence of β-N-methylamino-L-alanine (BMAA) and isomers in aquatic environments and aquatic food sources for humans [J]. Toxins, 2018, 10(2): 83. doi: 10.3390/toxins10020083
[38] COMBES A, EL ABDELLAOUI S, SARAZIN C, et al. Validation of the analytical procedure for the determination of the neurotoxin β-N-methylamino-L-alanine in complex environmental samples [J]. Analytica Chimica Acta, 2013, 771: 42-49. doi: 10.1016/j.aca.2013.02.016
[39] AL-SAMMAK M A, HOAGLAND K D, CASSADA D, et al. Co-occurrence of the cyanotoxins BMAA, DABA and Anatoxin-a in Nebraska reservoirs, fish, and aquatic plants [J]. Toxins, 2014, 6(2): 488-508. doi: 10.3390/toxins6020488
[40] CRAIGHEAD D, METCALF J S, BANACK S A, et al. Presence of the neurotoxic amino acids β-N-methylamino-L-alanine (BMAA) and 2, 4-diaminobutyric acid (DAB) in shallow springs from the Gobi Desert [J]. Amyotrophic Lateral Sclerosis, 2009, 10(sup2): 96-100. doi: 10.3109/17482960903278469
[41] FAASSEN E J, GILLISSEN F, ZWEERS H A J, et al. Determination of the neurotoxins BMAA (β-N-methylamino-L-alanine) and DAB (α-, γ-diaminobutyric acid) by LC-MSMS in Dutch urban waters with cyanobacterial blooms [J]. Amyotrophic Lateral Sclerosis, 2009, 10(sup2): 79-84. doi: 10.3109/17482960903272967
[42] METCALF J S, BANACK S A, LINDSAY J, et al. Co-occurrence of β-N-methylamino-L-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies, 1990-2004 [J]. Environmental Microbiology, 2008, 10(3): 702-708. doi: 10.1111/j.1462-2920.2007.01492.x
[43] ROY-LACHAPELLE A, SOLLIEC M, SAUVÉ S. Determination of BMAA and three alkaloid cyanotoxins in lake water using dansyl chloride derivatization and high-resolution mass spectrometry [J]. Analytical and Bioanalytical Chemistry, 2015, 407(18): 5487-5501. doi: 10.1007/s00216-015-8722-2
[44] 顾笑笑, 吴湘, 张爱, 等. 神经毒素BMAA在淡水池塘水体中的健康风险及调控技术 [J]. 水生生物学报, 2022, 46(2): 176-183. doi: 10.7541/2021.2021.012 GU X X, WU X, ZHANG A, et al. Health risk of neurotoxin β-N-methylamino-L-alanine(BMAA) in freshwater aquaculture ponds and its control technology [J]. Acta Hydrobiologica Sinica, 2022, 46(2): 176-183(in Chinese). doi: 10.7541/2021.2021.012
[45] WANG C, YAN C, QIU J B, et al. Food web biomagnification of the neurotoxin β-N-methylamino-L-alanine in a diatom-dominated marine ecosystem in China [J]. Journal of Hazardous Materials, 2021, 404: 124217. doi: 10.1016/j.jhazmat.2020.124217
[46] 李博. 藻毒素BMAA在土壤与作物间的迁移累积及其对秀丽隐杆线虫的影响[D]. 南京: 南京农业大学, 2019. LI B. Transfer and bioaccumulation of A cyanobacterial neurotoxin BMAA between soil and crop and its effects on Caenorhabditis elegans[D]. Nanjing: Nanjing Agricultural University, 2019(in Chinese).
[47] JIANG L Y, KISELOVA N, ROSÉN J, et al. Quantification of neurotoxin BMAA (β-N-methylamino-L-alanine) in seafood from Swedish markets [J]. Scientific Reports, 2014, 4: 6931. doi: 10.1038/srep06931
[48] RÉVEILLON D, ABADIE E, SÉCHET V, et al. β-N-methylamino-L-alanine (BMAA) and isomers: Distribution in different food web compartments of Thau lagoon, French Mediterranean Sea [J]. Marine Environmental Research, 2015, 110: 8-18. doi: 10.1016/j.marenvres.2015.07.015
[49] LAMPINEN SALOMONSSON M, HANSSON A, BONDESSON U. Development and in-house validation of a method for quantification of BMAA in mussels using dansyl chloride derivatization and ultra performance liquid chromatography tandem mass spectrometry [J]. Analytical Methods, 2013, 5(18): 4865. doi: 10.1039/c3ay40657a
[50] SCOTT L L, DOWNING S, DOWNING T. Potential for dietary exposure to β-N-methylamino-L-alanine and microcystin from a freshwater system [J]. Toxicon, 2018, 150: 261-266. doi: 10.1016/j.toxicon.2018.06.076
[51] CHRISTENSEN S J, HEMSCHEIDT T K, TRAPIDO-ROSENTHAL H, et al. Detection and quantification of β-methylamino-L-alanine in aquatic invertebrates [J]. Limnology and Oceanography:Methods, 2012, 10(11): 891-898. doi: 10.4319/lom.2012.10.891
[52] FIELD N C, METCALF J S, CALLER T A, et al. Linking β-methylamino-L-alanine exposure to sporadic amyotrophic lateral sclerosis in Annapolis, MD [J]. Toxicon, 2013, 70: 179-183. doi: 10.1016/j.toxicon.2013.04.010
[53] 陈咏梅, 赵以军, 陈默, 等. 武汉官桥湖蓝藻毒素BMAA的生物累积与健康风险评估 [J]. 水生态学杂志, 2019, 40(4): 22-29. doi: 10.15928/j.1674-3075.2019.04.004 CHEN Y M, ZHAO Y J, CHEN M, et al. Bioaccumulation and health risk assessment of the cyanobacterial neurotoxin BMAA in Guanqiao Lake, Wuhan [J]. Journal of Hydroecology, 2019, 40(4): 22-29(in Chinese). doi: 10.15928/j.1674-3075.2019.04.004
[54] WU X, WU H, GU X X, et al. Biomagnification characteristics and health risk assessment of the neurotoxin BMAA in freshwater aquaculture products of Taihu Lake Basin, China [J]. Chemosphere, 2019, 229: 332-340. doi: 10.1016/j.chemosphere.2019.04.210
[55] LI A F, SONG J L, HU Y, et al. New typical vector of neurotoxin β-N-methylamino-L-alanine (BMAA) in the marine benthic ecosystem [J]. Marine Drugs, 2016, 14(11): 202. doi: 10.3390/md14110202
[56] 王超, 邱江兵, 柳超, 等. 神经毒素BMAA沿海洋食物链的迁移转化行为研究[C]. 第十四届生物毒素毒理学术大会暨第一届生物毒素——从生存适应到转化医学专题学术会议会刊, 2019. WANG C, QIU J B, LIU C, et al. Migration and transformation behavior of neurotoxin BMAA along the Marine food chain[C]. Proceedings of the 14th Biotoxin Toxicology Conference and the 1st Biotoxin: From Survival Adaptation to Translational Medicine Symposium, 2019(in Chinese).
[57] HAMMERSCHLAG N, DAVIS D A, MONDO K, et al. Cyanobacterial neurotoxin BMAA and mercury in sharks [J]. Toxins, 2016, 8(8): 238. doi: 10.3390/toxins8080238
[58] MONDO K, HAMMERSCHLAG N, BASILE M, et al. Cyanobacterial neurotoxin β-N-methylamino-L-alanine (BMAA) in shark fins [J]. Marine Drugs, 2012, 10(2): 509-520.
[59] MONDO K, BROC GLOVER W, MURCH S J, et al. Environmental neurotoxins β-N-methylamino-L-alanine (BMAA) and mercury in shark cartilage dietary supplements [J]. Food Chem Toxicol, 2014, 70: 26-32. doi: 10.1016/j.fct.2014.04.015
[60] 焦一滢. 蓝藻神经毒素β-N-甲氨基-L-丙氨酸在太湖食物链中赋存与环境行为研究[D]. 南京: 南京大学, 2014. JIAO Y Y. Occurrence of the cyanobacterial neurotoxin β-N-methylamino-L-alanine in foodchains of lake Tai and the study of environmental fates[D]. Nanjing: Nanjing University, 2014(in Chinese).
[61] GANTAR M, SVIRČEV Z. Microalgae and cyanobacteria: Food for thought(1) [J]. Journal of Phycology, 2008, 44(2): 260-268. doi: 10.1111/j.1529-8817.2008.00469.x
[62] ROY-LACHAPELLE A, SOLLIEC M, BOUCHARD M F, et al. Detection of cyanotoxins in algae dietary supplements [J]. Toxins, 2017, 9(3): 76. doi: 10.3390/toxins9030076
[63] KRÜGER T, MÖNCH B, OPPENHÄUSER S, et al. LC-MS/MS determination of the isomeric neurotoxins BMAA (β-N-methylamino-L-alanine) and DAB (2, 4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius [J]. Toxicon, 2010, 55(2/3): 547-557.
[64] 樊华. 淡水蓝藻产生神经毒素BMAA和DAB的潜力及其环境影响因子研究[D]. 青岛: 中国海洋大学, 2013. FAN H. Potential production of neurotoxins BMAA and DAB in freshwater cyanobacteria and effects environmental factors[D]. Qingdao: Ocean University of China, 2013(in Chinese).
[65] DROBAC D, TOKODI N, SIMEUNOVIĆ J, et al. Human exposure to cyanotoxins and their effects on health [J]. Arhiv Za Higijenu Rada i Toksikologiju, 2013, 64(2): 119-130.
[66] FALCONER I R, HUMPAGE A R. Health risk assessment of cyanobacterial (blue-green algal) toxins in drinking water [J]. International Journal of Environmental Research and Public Health, 2005, 2(1): 43-50. doi: 10.3390/ijerph2005010043
[67] KARLSSON O, KULTIMA K, WADENSTEN H, et al. Neurotoxin-induced neuropeptide perturbations in striatum of neonatal rats [J]. Journal of Proteome Research, 2013, 12(4): 1678-1690. doi: 10.1021/pr3010265
[68] 全国居民主要食品消费量[EB/OL]. 国家统计局, 2013-2020. National consumption of major food products[EB/OL]. National Bureau of Statistics, 2013-2020.
[69] 闫云君, 梁彦龄. 水生大型无脊椎动物的干湿重比的研究 [J]. 华中理工大学学报, 1999, 27(9): 61-63. YAN Y J, LIANG Y L. A study of dry to wet weight ratio of aquatic macroinvertebrates [J]. Journal of Huazhong University of Science and Technology, 1999, 27(9): 61-63(in Chinese).