安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究

刘敏, 殷浩文, 王绿平, 王樱芝, 沈璐, 朱慧. 安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究[J]. 生态毒理学报, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002
引用本文: 刘敏, 殷浩文, 王绿平, 王樱芝, 沈璐, 朱慧. 安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究[J]. 生态毒理学报, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002
Liu Min, Yin Haowen, Wang Lvping, Wang Yingzhi, Shen Lu, Zhu Hui. Study of Aquatic Acute Toxicity of Metamizole Metabolites 4-Acetamidoantipyrine[J]. Asian Journal of Ecotoxicology, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002
Citation: Liu Min, Yin Haowen, Wang Lvping, Wang Yingzhi, Shen Lu, Zhu Hui. Study of Aquatic Acute Toxicity of Metamizole Metabolites 4-Acetamidoantipyrine[J]. Asian Journal of Ecotoxicology, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002

安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究

    作者简介: 刘敏(1980-),女,博士,高级工程师,研究方向为环境污染物分析及化学品风险评价,E-mail:lium@apm.sh.cn
  • 基金项目:

    上海市卫生体系建设第四轮三年行动计划重点学科建设项目(15GWZK0201)

  • 中图分类号: X171.5

Study of Aquatic Acute Toxicity of Metamizole Metabolites 4-Acetamidoantipyrine

  • Fund Project:
  • 摘要: 在地表水中检出高浓度的安乃近代谢产物4-乙酰氨基安替比林(4-AAA),但目前缺乏对4-AAA的生态毒性研究,故无法评价其生态风险。采用经济合作与发展组织(OECD)标准测试方法,研究4-AAA对藻、大型溞和鱼的急性毒性效应。结果表明,在1 500 mg·L-1(配制浓度)4-AAA的暴露条件下,近头状伪蹄形藻(Pseudokirchneriella subcapitata)的生长并没有受到明显抑制效应;稀有鮈鲫(Gobiocypris rarus)没有发现死亡现象。这表明,藻类生长量和生长率的72 h无可观察效应浓度(NOEC)均≥ 1 502 mg·L-1(实测浓度),96 h鱼类急性毒性的半致死浓度(LC50)≥ 1 532 mg·L-1(实测浓度)。当大型溞(Daphnia magna)暴露于一系列不同浓度4-AAA(188、375、750、1 500和3 000 mg·L-1),24 h后发现750 mg·L-1的暴露组开始出现运动抑制现象;最高浓度组中,80%大型溞的运动能力明显受到抑制。48 h后抑制效应增加,750 mg·L-1暴露组中,40%的大型溞活动能力受到抑制;最高浓度组仅20%大型溞活动能力保持正常。这表明,高浓度4-AAA对大型溞的活动能力具有一定的抑制作用。统计分析结果表明,24 h和48 h大型溞活动能力的抑制效应达一半的浓度(EC50)分别为1 538 mg·L-1(1 217~2 017 mg·L-1)和1 041 mg·L-1(834~1 304 mg·L-1)。根据全球化学品统一分类和标签制度(GHS)分类,4-AAA的水生急性毒性不归类。尽管地表水中检出高浓度(3 675 ng·L-1)的4-AAA,但最高风险商值仅为3.53×10-3,风险较低。
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  • 收稿日期:  2020-01-15
刘敏, 殷浩文, 王绿平, 王樱芝, 沈璐, 朱慧. 安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究[J]. 生态毒理学报, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002
引用本文: 刘敏, 殷浩文, 王绿平, 王樱芝, 沈璐, 朱慧. 安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究[J]. 生态毒理学报, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002
Liu Min, Yin Haowen, Wang Lvping, Wang Yingzhi, Shen Lu, Zhu Hui. Study of Aquatic Acute Toxicity of Metamizole Metabolites 4-Acetamidoantipyrine[J]. Asian Journal of Ecotoxicology, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002
Citation: Liu Min, Yin Haowen, Wang Lvping, Wang Yingzhi, Shen Lu, Zhu Hui. Study of Aquatic Acute Toxicity of Metamizole Metabolites 4-Acetamidoantipyrine[J]. Asian Journal of Ecotoxicology, 2020, 15(3): 108-115. doi: 10.7524/AJE.1673-5897.20200115002

安乃近代谢产物4-乙酰氨基安替比林的水生急性毒性研究

    作者简介: 刘敏(1980-),女,博士,高级工程师,研究方向为环境污染物分析及化学品风险评价,E-mail:lium@apm.sh.cn
  • 上海市检测中心生物与安全检测实验室, 上海 201203
基金项目:

上海市卫生体系建设第四轮三年行动计划重点学科建设项目(15GWZK0201)

摘要: 在地表水中检出高浓度的安乃近代谢产物4-乙酰氨基安替比林(4-AAA),但目前缺乏对4-AAA的生态毒性研究,故无法评价其生态风险。采用经济合作与发展组织(OECD)标准测试方法,研究4-AAA对藻、大型溞和鱼的急性毒性效应。结果表明,在1 500 mg·L-1(配制浓度)4-AAA的暴露条件下,近头状伪蹄形藻(Pseudokirchneriella subcapitata)的生长并没有受到明显抑制效应;稀有鮈鲫(Gobiocypris rarus)没有发现死亡现象。这表明,藻类生长量和生长率的72 h无可观察效应浓度(NOEC)均≥ 1 502 mg·L-1(实测浓度),96 h鱼类急性毒性的半致死浓度(LC50)≥ 1 532 mg·L-1(实测浓度)。当大型溞(Daphnia magna)暴露于一系列不同浓度4-AAA(188、375、750、1 500和3 000 mg·L-1),24 h后发现750 mg·L-1的暴露组开始出现运动抑制现象;最高浓度组中,80%大型溞的运动能力明显受到抑制。48 h后抑制效应增加,750 mg·L-1暴露组中,40%的大型溞活动能力受到抑制;最高浓度组仅20%大型溞活动能力保持正常。这表明,高浓度4-AAA对大型溞的活动能力具有一定的抑制作用。统计分析结果表明,24 h和48 h大型溞活动能力的抑制效应达一半的浓度(EC50)分别为1 538 mg·L-1(1 217~2 017 mg·L-1)和1 041 mg·L-1(834~1 304 mg·L-1)。根据全球化学品统一分类和标签制度(GHS)分类,4-AAA的水生急性毒性不归类。尽管地表水中检出高浓度(3 675 ng·L-1)的4-AAA,但最高风险商值仅为3.53×10-3,风险较低。

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