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Yang Yan, Gao Yuan, Ma Shengtao, Gong Jian, Yu Yingxin. Composition, Isomer-specific Occurrences, Environmental Fate and Toxicity of Nonylphenols: A Review[J]. Asian Journal of Ecotoxicology, 2023, 18(1): 206-216. doi: 10.7524/AJE.1673-5897.20220214002
Citation: Yang Yan, Gao Yuan, Ma Shengtao, Gong Jian, Yu Yingxin. Composition, Isomer-specific Occurrences, Environmental Fate and Toxicity of Nonylphenols: A Review[J]. Asian Journal of Ecotoxicology, 2023, 18(1): 206-216. doi: 10.7524/AJE.1673-5897.20220214002
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Composition, Isomer-specific Occurrences, Environmental Fate and Toxicity of Nonylphenols: A Review

  • 1. Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China;

  • 2. Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515041, China;

  • 3. Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China

  • Corresponding author: Ma Shengtao, mast@gdut.edu.cn ; 
  • Received Date: 14/02/2022
    Accepted Date: 26/04/2022
    Fund Project:
  • Nonylphenols (NPs) is a toxic xenobiotic compound, which is identified as an environmental endocrine disruptor. Due to its lipophilicity, NPs can easily sorb onto soils and sediments, and persist in the environment for long time. NPs accumulate in various organs and pose toxic effects on organisms. It has been listed as new pollutant under “China’s 14th Five-Year Plan”, with strict usage prohibition. Theoretically, technical nonylphenol consists of a mixture of 211 possible constitutional isomers with a varied and undefined degree of branching in the alkyl group, among them about 50～80 individual isomers have been identified in technical mixtures. There is sufficient scientific evidence that the toxicological effects (estrogenic activity), as well as the environmental behavior (degradation and accumulation) of isomers can vary. Therefore, it is necessary to consider the nonylphenol problem from an isomer-specific viewpoint in environmental, exposure, and health studies, which can serve as a fundament for its accurate assessment and prediction of potential health risks. In the present review, the recent advancements and future trends on the isomer composition, isomer-specific occurrences, environmental fate, and toxicity of nonylphenols were summarized. The perspectives and challenges are identified for future studies.
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Composition, Isomer-specific Occurrences, Environmental Fate and Toxicity of Nonylphenols: A Review

  • Received Date: 14/02/2022
  • Accepted Date: 26/04/2022
Fund Project:

Abstract: Nonylphenols (NPs) is a toxic xenobiotic compound, which is identified as an environmental endocrine disruptor. Due to its lipophilicity, NPs can easily sorb onto soils and sediments, and persist in the environment for long time. NPs accumulate in various organs and pose toxic effects on organisms. It has been listed as new pollutant under “China’s 14th Five-Year Plan”, with strict usage prohibition. Theoretically, technical nonylphenol consists of a mixture of 211 possible constitutional isomers with a varied and undefined degree of branching in the alkyl group, among them about 50～80 individual isomers have been identified in technical mixtures. There is sufficient scientific evidence that the toxicological effects (estrogenic activity), as well as the environmental behavior (degradation and accumulation) of isomers can vary. Therefore, it is necessary to consider the nonylphenol problem from an isomer-specific viewpoint in environmental, exposure, and health studies, which can serve as a fundament for its accurate assessment and prediction of potential health risks. In the present review, the recent advancements and future trends on the isomer composition, isomer-specific occurrences, environmental fate, and toxicity of nonylphenols were summarized. The perspectives and challenges are identified for future studies.

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