Peng Ying, Zhang Hanxin, Zhang Xiaowei. Research Advance of Quantitative Adverse Outcome Pathways (qAOPs) in Environmental Chemicals Toxicity Assessment Ⅰ: Model Building and Application Cases[J]. Asian journal of ecotoxicology, 2021, 16(3): 1-13. doi: 10.7524/AJE.1673-5897.20201024001
Citation: Peng Ying, Zhang Hanxin, Zhang Xiaowei. Research Advance of Quantitative Adverse Outcome Pathways (qAOPs) in Environmental Chemicals Toxicity Assessment Ⅰ: Model Building and Application Cases[J]. Asian journal of ecotoxicology, 2021, 16(3): 1-13. doi: 10.7524/AJE.1673-5897.20201024001

Research Advance of Quantitative Adverse Outcome Pathways (qAOPs) in Environmental Chemicals Toxicity Assessment Ⅰ: Model Building and Application Cases

  • Corresponding author: Zhang Xiaowei, zhangxw@nju.edu.cn
  • Received Date: 24/10/2020
    Fund Project:
  • Over the past decade, the development of adverse outcome pathway (AOP) framework has matured significantly, which has been considered as a new approach for organizing biological information into a format and applicable method for chemical safety evaluation in both human health and ecological contexts. Ultimately, it is developed for use in the assessment and regulation of chemicals, including the priority assessment and hazard prediction. Based on above, AOP will contribute to the realization of the risk assessment and application in regulatory decision making. Although the development of AOP frameworks has made great progress, its effective application to chemical regulation requires a detailed quantitative description of the relationship among the molecular priming events, key events and the adverse outcome. Consequently, quantitative AOPs (qAOPs) is critical for AOP application. At first, this review summarizes the development status of AOP framework, including AOP knowledge base (AOP KB), qualitative AOPs and quantitative AOPs. Secondly, this review describes how qAOP models can be developed and provides examples of how they could be used in a hazard or risk assessment context. Finally, the most important issues and potential solutions in the current qAOPs development process are discussed in this review, the future research and application of qAOPs in the hazard assessment of environment chemicals and environmental mixtures are also prospected.
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Research Advance of Quantitative Adverse Outcome Pathways (qAOPs) in Environmental Chemicals Toxicity Assessment Ⅰ: Model Building and Application Cases

Fund Project:

Abstract: Over the past decade, the development of adverse outcome pathway (AOP) framework has matured significantly, which has been considered as a new approach for organizing biological information into a format and applicable method for chemical safety evaluation in both human health and ecological contexts. Ultimately, it is developed for use in the assessment and regulation of chemicals, including the priority assessment and hazard prediction. Based on above, AOP will contribute to the realization of the risk assessment and application in regulatory decision making. Although the development of AOP frameworks has made great progress, its effective application to chemical regulation requires a detailed quantitative description of the relationship among the molecular priming events, key events and the adverse outcome. Consequently, quantitative AOPs (qAOPs) is critical for AOP application. At first, this review summarizes the development status of AOP framework, including AOP knowledge base (AOP KB), qualitative AOPs and quantitative AOPs. Secondly, this review describes how qAOP models can be developed and provides examples of how they could be used in a hazard or risk assessment context. Finally, the most important issues and potential solutions in the current qAOPs development process are discussed in this review, the future research and application of qAOPs in the hazard assessment of environment chemicals and environmental mixtures are also prospected.

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