| Kumar M, Sarma D K, Shubham S, et al. Environmental endocrine-disrupting chemical exposure: Role in non-communicable diseases [J]. Frontiers in Public Health, 2020, 8: 553850 |
| Zoeller R T, Brown T R, Doan L L, et al. Endocrine-disrupting chemicals and public health protection: A statement of principles from The Endocrine Society [J]. Endocrinology, 2012, 153(9): 4097-4110 |
| Maqbool F, Mostafalou S, Bahadar H, et al. Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms [J]. Life Sciences, 2016, 145: 265-273 |
| Oyola M G, Handa R J. Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: Sex differences in regulation of stress responsivity [J]. Stress, 2017, 20(5): 476-494 |
| Melgarejo M, Mendiola J, Koch H M, et al. Associations between urinary organophosphate pesticide metabolite levels and reproductive parameters in men from an infertility clinic [J]. Environmental Research, 2015, 137: 292-298 |
| Ye X Q, Pan W Y, Zhao S L, et al. Relationships of pyrethroid exposure with gonadotropin levels and pubertal development in Chinese boys [J]. Environmental Science & Technology, 2017, 51(11): 6379-6386 |
| Kaprara A, Huhtaniemi I T. The hypothalamus-pituitary-gonad axis: Tales of mice and men [J]. Metabolism, 2018, 86: 3-17 |
| Stamatiades G A, Kaiser U B. Gonadotropin regulation by pulsatile GnRH: Signaling and gene expression [J]. Molecular and Cellular Endocrinology, 2018, 463: 131-141 |
| Plunk E C, Richards S M. Endocrine-disrupting air pollutants and their effects on the hypothalamus-pituitary-gonadal axis [J]. International Journal of Molecular Sciences, 2020, 21(23): 9191 |
| Dwyer A A, Chavan N R, Lewkowitz-Shpuntoff H, et al. Functional hypogonadotropic hypogonadism in men: Underlying neuroendocrine mechanisms and natural history [J]. The Journal of Clinical Endocrinology & Metabolism, 2019, 104(8): 3403-3414 |
| Goodarzi M O, Dumesic D A, Chazenbalk G, et al. Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis [J]. Nature Reviews Endocrinology, 2011(7): 219-231 |
| Saadia Z. Follicle stimulating hormone (LH: FSH) ratio in polycystic ovary syndrome (PCOS)-obese vs. non-obese women [J]. Medical Archives, 2020, 74(4): 289 |
| McKinlay R, Plant J A, Bell J N B, et al. Endocrine disrupting pesticides: Implications for risk assessment [J]. Environment International, 2008, 34(2): 168-183 |
| Bornman M, Delport R, Farías P, et al. Alterations in male reproductive hormones in relation to environmental DDT exposure [J]. Environment International, 2018, 113: 281-289 |
| Freire C, Koifman R J, Sarcinelli P N, et al. Association between serum levels of organochlorine pesticides and sex hormones in adults living in a heavily contaminated area in Brazil [J]. International Journal of Hygiene and Environmental Health, 2014, 217(2-3): 370-378 |
| Eskenazi B, Rauch S A, Tenerelli R, et al. In utero and childhood DDT, DDE, PBDE and PCBs exposure and sex hormones in adolescent boys: The CHAMACOS study [J]. International Journal of Hygiene and Environmental Health, 2017, 220(2): 364-372 |
| Aguilar-Garduño C, Lacasaña M, Blanco-Muñoz J, et al. Changes in male hormone profile after occupational organophosphate exposure. A longitudinal study [J]. Toxicology, 2013, 307: 55-65 |
| Qin K L, Zhang Y, Wang Y W, et al. Prenatal organophosphate pesticide exposure and reproductive hormones in cord blood in Shandong, China [J]. International Journal of Hygiene and Environmental Health, 2020, 225: 113479 |
| Li C M, Cao M F, Ma L J, et al. Pyrethroid pesticide exposure and risk of primary ovarian insufficiency in Chinese women [J]. Environmental Science & Technology, 2018, 52(5): 3240-3248 |
| Jurewicz J, Radwan P, Wielgomas B, et al. Exposure to pyrethroid pesticides and ovarian reserve [J]. Environment International, 2020, 144: 106028 |
| Hoh E, Zhu L Y, Hites R A. Dechlorane plus, a chlorinated flame retardant, in the Great Lakes [J]. Environmental Science & Technology, 2006, 40(4): 1184-1189 |
| Zhu J P, Feng Y L, Shoeib M. Detection of dechlorane plus in residential indoor dust in the city of Ottawa, Canada [J]. Environmental Science & Technology, 2007, 41(22): 7694-7698 |
| Siddique S, Xian Q M, Abdelouahab N, et al. Levels of dechlorane plus and polybrominated diphenylethers in human milk in two Canadian cities [J]. Environment International, 2012, 39(1): 50-55 |
| Ren G F, Yu Z Q, Ma S T, et al. Determination of dechlorane plus in serum from electronics dismantling workers in South China [J]. Environmental Science & Technology, 2009, 43(24): 9453-9457 |
| Johnson P I, Stapleton H M, Mukherjee B, et al. Associations between brominated flame retardants in house dust and hormone levels in men [J]. Science of the Total Environment, 2013, 445-446: 177-184 |
| Makey C M, McClean M D, Braverman L E, et al. Polybrominated diphenyl ether exposure and reproductive hormones in North American men [J]. Reproductive Toxicology, 2016, 62: 46-52 |
| Gao Y, Chen L M, Wang C F, et al. Exposure to polybrominated diphenyl ethers and female reproductive function: A study in the production area of Shandong, China [J]. Science of the Total Environment, 2016, 572: 9-15 |
| Gravel S, Lavoué J, Bakhiyi B, et al. Multi-exposures to suspected endocrine disruptors in electronic waste recycling workers: Associations with thyroid and reproductive hormones [J]. International Journal of Hygiene and Environmental Health, 2020, 225: 113445 |
| Pan W Y, Ye X Q, Yin S S, et al. Selected persistent organic pollutants associated with the risk of primary ovarian insufficiency in women [J]. Environment International, 2019, 129: 51-58 |
| Tang M L, Yin S S, Zhang J Y, et al. Prenatal exposure to polychlorinated biphenyl and umbilical cord hormones and birth outcomes in an island population [J]. Environmental Pollution, 2018, 237: 581-591 |
| Miyashita C, Araki A, Mitsui T, et al. Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study [J]. Environment International, 2018, 117: 175-185 |
| Casals-Casas C, Desvergne B. Endocrine disruptors: From endocrine to metabolic disruption [J]. Annual Review of Physiology, 2011, 73: 135-162 |
| Adoamnei E, Mendiola J, Vela-Soria F, et al. Urinary bisphenol A concentrations are associated with reproductive parameters in young men [J]. Environmental Research, 2018, 161: 122-128 |
| Gao C Z, He H H, Qiu W H, et al. Oxidative stress, endocrine disturbance, and immune interference in humans showed relationships to serum bisphenol concentrations in a dense industrial area [J]. Environmental Science & Technology, 2021, 55(3): 1953-1963 |
| Lassen T H, Frederiksen H, Jensen T K, et al. Urinary bisphenol A levels in young men: Association with reproductive hormones and semen quality [J]. Environmental Health Perspectives, 2014, 122(5): 478-484 |
| Liang H, Xu W P, Chen J P, et al. The association between exposure to environmental bisphenol A and gonadotropic hormone levels among men [J]. PLoS One, 2017, 12(1): e0169217 |
| Meeker J D, Calafat A M, Hauser R. Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic [J]. Environmental Science & Technology, 2010, 44(4): 1458-1463 |
| Chen Y, Wang Y C, Ding G D, et al. Association between bisphenol A exposure and idiopathic central precocious puberty (ICPP) among school-aged girls in Shanghai, China [J]. Environment International, 2018, 115: 410-416 |
| Hyun Kim D, Min Choi S, Soo Lim D, et al. Risk assessment of endocrine disrupting phthalates and hormonal alterations in children and adolescents [J]. Journal of Toxicology and Environmental Health, Part A, 2018, 81(21): 1150-1164 |
| Wang B, Qin X L, Xiao N, et al. Phthalate exposure and semen quality in infertile male population from Tianjin, China: Associations and potential mediation by reproductive hormones [J]. Science of the Total Environment, 2020, 744: 140673 |
| Chen Q, Yang H, Zhou N Y, et al. Phthalate exposure, even below US EPA reference doses, was associated with semen quality and reproductive hormones: Prospective MARHCS study in general population [J]. Environment International, 2017, 104: 58-68 |
| Muerköster A P, Frederiksen H, Juul A, et al. Maternal phthalate exposure associated with decreased testosterone/LH ratio in male offspring during mini-puberty. Odense Child Cohort [J]. Environment International, 2020, 144: 106025 |
| Cao M F, Pan W Y, Shen X Y, et al. Urinary levels of phthalate metabolites in women associated with risk of premature ovarian failure and reproductive hormones [J]. Chemosphere, 2020, 242: 125206 |
| Guth M, Pollock T, Fisher M, et al. Concentrations of urinary parabens and reproductive hormones in girls 6-17 years living in Canada [J]. International Journal of Hygiene and Environmental Health, 2021, 231: 113633 |
| Jensen T K, Andersson A M, Main K M, et al. Prenatal paraben exposure and anogenital distance and reproductive hormones during mini-puberty: A study from the Odense Child Cohort [J]. Science of the Total Environment, 2021, 769: 145119 |
| Janjua N R, Mortensen G K, Andersson A M, et al. Systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole-body topical application and reproductive and thyroid hormone levels in humans [J]. Environmental Science & Technology, 2007, 41(15): 5564-5570 |
| Smith K W, Souter I, Dimitriadis I, et al. Urinary paraben concentrations and ovarian aging among women from a fertility center [J]. Environmental Health Perspectives, 2013, 121(11-12): 1299-1305 |
| Jurewicz J, Radwan M, Wielgomas B, et al. Parameters of ovarian reserve in relation to urinary concentrations of parabens [J]. Environmental Health, 2020, 19(1): 26 |
| Liang Y S, Tang Z, Jiang Y S, et al. Serum metabolic changes associated with dioxin exposure in a Chinese male cohort [J]. Environment International, 2020, 143: 105984 |
| Patrizi B, Siciliani de Cumis M. TCDD toxicity mediated by epigenetic mechanisms [J]. International Journal of Molecular Sciences, 2018, 19(12): 4101 |
| Mocarelli P, Gerthoux P M, Needham L L, et al. Perinatal exposure to low doses of dioxin can permanently impair human semen quality [J]. Environmental Health Perspectives, 2011, 119(5): 713-718 |
| Lambertino A, Persky V, Freels S, et al. Associations of PCBS, dioxins and furans with follicle-stimulating hormone and luteinizing hormone in postmenopausal women: National Health and Nutrition Examination Survey 1999-2002 [J]. Chemosphere, 2021, 262: 128309 |
| Ye X Q, Pan W Y, Li C M, et al. Exposure to polycyclic aromatic hydrocarbons and risk for premature ovarian failure and reproductive hormones imbalance [J]. Journal of Environmental Sciences, 2020, 91: 1-9 |
| Yin S S, Tang M L, Chen F F, et al. Environmental exposure to polycyclic aromatic hydrocarbons (PAHs): The correlation with and impact on reproductive hormones in umbilical cord serum [J]. Environmental Pollution, 2017, 220: 1429-1437 |
| Chen Q, Wang F R, Yang H, et al. Exposure to fine particulate matter-bound polycyclic aromatic hydrocarbons, male semen quality, and reproductive hormones: The MARCHS study [J]. Environmental Pollution, 2021, 280: 116883 |
| Interdonato M, Pizzino G, Bitto A, et al. Cadmium delays puberty onset and testis growth in adolescents [J]. Clinical Endocrinology, 2015, 83(3): 357-362 |
| Ciarrocca M, Capozzella A, Tomei F, et al. Exposure to cadmium in male urban and rural workers and effects on FSH, LH and testosterone [J]. Chemosphere, 2013, 90(7): 2077-2084 |
| Jackson L W, Howards P P, Wactawski-Wende J, et al. The association between cadmium, lead and mercury blood levels and reproductive hormones among healthy, premenopausal women [J]. Human Reproduction, 2011, 26(10): 2887-2895 |
| Pollack A Z, Schisterman E F, Goldman L R, et al. Cadmium, lead, and mercury in relation to reproductive hormones and anovulation in premenopausal women [J]. Environmental Health Perspectives, 2011, 119(8): 1156-1161 |
| Pan W Y, Ye X Q, Zhu Z Y, et al. Urinary cadmium concentrations and risk of primary ovarian insufficiency in women: A case-control study [J]. Environmental Geochemistry and Health, 2021, 43(5): 2025-2035 |
| Lee T W, Kim D H, Ryu J Y. The effects of exposure to lead, cadmium and mercury on follicle-stimulating hormone levels in men and postmenopausal women: Data from the Second Korean National Environmental Health Survey (2012-2014) [J]. Annals of Occupational and Environmental Medicine, 2019, 31: e21 |
| Dehghan S F, Mehrifar Y, Ardalan A. The relationship between exposure to lead-containing welding fumes and the levels of reproductive hormones [J]. Annals of Global Health, 2019, 85(1): 125 |
| Ben Rhouma K, Tébourbi O, Krichah R, et al. Reproductive toxicity of DDT in adult male rats [J]. Human & Experimental Toxicology, 2001, 20(8): 393-397 |
| Rasier G, Parent A S, Gérard A, et al. Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane [J]. Biology of Reproduction, 2007, 77(4): 734-742 |
| Alaa-Eldin E A, El-Shafei D A, Abouhashem N S. Individual and combined effect of chlorpyrifos and cypermethrin on reproductive system of adult male albino rats [J]. Environmental Science and Pollution Research International, 2017, 24(2): 1532-1543 |
| Ye X Q, Li F X, Zhang J Y, et al. Pyrethroid insecticide cypermethrin accelerates pubertal onset in male mice via disrupting hypothalamic-pituitary-gonadal axis [J]. Environmental Science & Technology, 2017, 51(17): 10212-10221 |
| Zhang S Y, Ito Y, Yamanoshita O, et al. Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of leydig cells in adult male mouse [J]. Endocrinology, 2007, 148(8): 3941-3949 |
| Zhou Y J, Wang X D, Xiao S, et al. Exposure to beta-cypermethrin impairs the reproductive function of female mice [J]. Regulatory Toxicology and Pharmacology, 2018, 95: 385-394 |
| Li Y F, Pan C, Hu J X, et al. Effects of cypermethrin on male reproductive system in adult rats [J]. Biomedical and Environmental Sciences, 2013, 26(3): 201-208 |
| Simon-Delso N, Amaral-Rogers V, Belzunces L P, et al. Systemic insecticides (neonicotinoids and fipronil): Trends, uses, mode of action and metabolites [J]. Environmental Science and Pollution Research International, 2015, 22(1): 5-34 |
| Bass C, Field L M. Neonicotinoids [J]. Current Biology, 2018, 28(14): R772-R773 |
| Kapoor U, Srivastava M K, Srivastava L P. Toxicological impact of technical imidacloprid on ovarian morphology, hormones and antioxidant enzymes in female rats [J]. Food and Chemical Toxicology, 2011, 49(12): 3086-3089 |
| Abdel-Razik R K, Mosallam E M, Hamed N A, et al. Testicular deficiency associated with exposure to cypermethrin, imidacloprid, and chlorpyrifos in adult rats [J]. Environmental Toxicology and Pharmacology, 2021, 87: 103724 |
| Arıcan E Y, Gökçeoğlu Kayalı D, Ulus Karaca B, et al. Reproductive effects of subchronic exposure to acetamiprid in male rats [J]. Scientific Reports, 2020, 10(1): 8985 |
| Li Z Q, Li H T, Li C C, et al. Low dose of fire retardant, 2,2’,4,4’-tetrabromodiphenyl ether (BDE47), stimulates the proliferation and differentiation of progenitor Leydig cells of male rats during prepuberty [J]. Toxicology Letters, 2021, 342: 6-19 |
| Lefèvre P L C, Berger R G, Ernest S R, et al. Exposure of female rats to an environmentally relevant mixture of brominated flame retardants targets the ovary, affecting folliculogenesis and steroidogenesis [J]. Biology of Reproduction, 2016, 94(1): 9, 1-11 |
| Steinberg R M, Walker D M, Juenger T E, et al. Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: Development, reproductive physiology, and second generational effects [J]. Biology of Reproduction, 2008, 78(6): 1091-1101 |
| Yamamoto M, Narita A, Kagohata M, et al. Effects of maternal exposure to 3,3’,4,4’,5-pentachlorobiphenyl (PCB126) or 3,3’,4,4’,5,5’-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats [J]. Journal of Andrology, 2005, 26(2): 205-214 |
| Fiandanese N, Borromeo V, Berrini A, et al. Maternal exposure to a mixture of di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) causes reproductive dysfunction in adult male mouse offspring [J]. Reproductive Toxicology, 2016, 65: 123-132 |
| Oliveira I M, Romano R M, de Campos P, et al. Delayed onset of puberty in male offspring from bisphenol A-treated dams is followed by the modulation of gene expression in the hypothalamic-pituitary-testis axis in adulthood [J]. Reproduction, Fertility and Development, 2017, 29(12): 2496 |
| Yuan M, Zhao Y N, Lin R, et al. Adverse reproductive function induced by maternal BPA exposure is associated with abnormal autophagy and activating inflamation via mTOR and TLR4/NF-κB signaling pathways in female offspring rats [J]. Reproductive Toxicology, 2020, 96: 185-194 |
| Ullah A, Pirzada M, Jahan S, et al. Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action [J]. Food and Chemical Toxicology, 2018, 121: 24-36 |
| Nourian A, Soleimanzadeh A, Shalizar Jalali A, et al. Bisphenol-A analogue (bisphenol-S) exposure alters female reproductive tract and apoptosis/oxidative gene expression in blastocyst-derived cells [J]. Iranian Journal of Basic Medical Sciences, 2020, 23(5): 576-585 |
| Giribabu N, Reddy P S. Protection of male reproductive toxicity in rats exposed to di-n-butyl phthalate during embryonic development by testosterone [J]. Biomedicine & Pharmacotherapy, 2017, 87: 355-365 |
| 于淼, 张林媛, 乔佩环, 等. 邻苯二甲酸二丁酯诱导氧化应激及抑制CYP17a1干扰睾酮合成[J]. 卫生研究, 2015, 44(3): 364-370 Yu M, Zhang L Y, Qiao P H, et al. Testicular oxidative stress and downregulation of CYP17a1 induced by di(n-butyl) phthalate inhibit synthesis of testosterone [J]. Journal of Hygiene Research, 2015, 44(3): 364-370 (in Chinese) |
| Nelli G, Pamanji S R. Di-n-butyl phthalate prompts interruption of spermatogenesis, steroidogenesis, and fertility associated with increased testicular oxidative stress in adult male rats [J]. Environmental Science and Pollution Research International, 2017, 24(22): 18563-18574 |
| Ha M, Guan X, Wei L, et al. Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5α-Reductase 2 [J]. Science of the Total Environment, 2016, 563-564: 566-575 |
| Yue M, Ma R S, Zhang R Z, et al. Effects of dimethyl phthalate (DMP) on serum sex hormone levels and apoptosis in C57 female mice [J]. International Journal of Endocrinology and Metabolism, 2019, 17(2): e82882 |
| Guerra M T, Sanabria M, Leite G A A, et al. Maternal exposure to butyl paraben impairs testicular structure and sperm quality on male rats [J]. Environmental Toxicology, 2017, 32(4): 1273-1289 |
| Zhang L Y, Dong L, Ding S J, et al. Effects of n-butylparaben on steroidogenesis and spermatogenesis through changed E2 levels in male rat offspring [J]. Environmental Toxicology and Pharmacology, 2014, 37(2): 705-717 |
| Maske P, Dighe V, Mote C, et al. n-butylparaben exposure through gestation and lactation impairs spermatogenesis and steroidogenesis causing reduced fertility in the F1 generation male rats [J]. Environmental Pollution, 2020, 256: 112957 |
| Takeda T, Matsumoto Y, Koga T, et al. Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior [J]. The Journal of Pharmacology and Experimental Therapeutics, 2009, 329(3): 1091-1099 |
| Yu K L, Zhang X L, Tan X M, et al. Transgenerational impairment of ovarian induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) associated with Igf2 and H19 in adult female rat [J]. Toxicology, 2019, 428: 152311 |
| Li X S, Guo J T, Jiang X W, et al. Cyanidin-3-O-glucoside protects against cadmium-induced dysfunction of sex hormone secretion via the regulation of hypothalamus-pituitary-gonadal axis in male pubertal mice [J]. Food and Chemical Toxicology, 2019, 129: 13-21 |
| da Costa C S, Oliveira T F, Freitas-Lima L C, et al. Subacute cadmium exposure disrupts the hypothalamic-pituitary-gonadal axis, leading to polycystic ovarian syndrome and premature ovarian failure features in female rats [J]. Environmental Pollution, 2021, 269: 116154 |
| Madboli A E N A, Seif M M. Immunohistochemical, histopathological, and biochemical studies of the NF-B P65 marker in rat ovaries experimentally intoxicated by cadmium and the protective effect of the purslane plant extract [J]. Environmental Science and Pollution Research International, 2021, 28(14): 17613-17626 |
| Wang J C, Zhu H L, Lin S, et al. Protective effect of naringenin against cadmium-induced testicular toxicity in male SD rats [J]. Journal of Inorganic Biochemistry, 2021, 214: 111310 |
| Alotaibi M F, Al-Joufi F, Abou Seif H S, et al. Umbelliferone inhibits spermatogenic defects and testicular injury in lead-intoxicated rats by suppressing oxidative stress and inflammation, and improving Nrf2/HO-1 signaling [J]. Drug Design, Development and Therapy, 2020, 14: 4003-4019 |
| Svechnikova I, Svechnikov K, Söder O. The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats [J]. The Journal of Endocrinology, 2007, 194(3): 603-609 |
| Zhou J H, Yang Y, Xiong K, et al. Endocrine disrupting effects of dichlorodiphenyltrichloroethane analogues on gonadotropin hormones in pituitary gonadotrope cells [J]. Environmental Toxicology and Pharmacology, 2014, 37(3): 1194-1201 |
| Li F X, Ma H H, Liu J. Pyrethroid insecticide cypermethrin modulates gonadotropin synthesis via calcium homeostasis and ERK1/2 signaling in LβT2 mouse pituitary cells [J]. Toxicological Sciences, 2017, 162(1): 43-52 |
| Xin F, Susiarjo M, Bartolomei M S. Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation? [J]. Seminars in Cell & Developmental Biology, 2015, 43: 66-75 |
| Latchney S E, Fields A M, Susiarjo M. Linking inter-individual variability to endocrine disruptors: Insights for epigenetic inheritance [J]. Mammalian Genome, 2018, 29(1-2): 141-152 |
| Takeda T, Fujii M, Taura J, et al. Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: A new insight into the mechanism for the imprinting of sexual immaturity by dioxin [J]. Journal of Biological Chemistry, 2012, 287(22): 18440-18450 |