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-. 北加利福尼亚州猫类血清中的全氟和多氟化合物浓度:时间尺度上的对比以及与甲状腺机能亢进的关联性[J]. 生态毒理学报, 2018, 13(5):
北加利福尼亚州猫类血清中的全氟和多氟化合物浓度:时间尺度上的对比以及与甲状腺机能亢进的关联性
Per- and Polyfluoroalkyl Substances in Northern California Cats: Temporal Comparison and a Possible Link to Cat Hyperthyroidism
  
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中文摘要:
      室内环境暴露和膳食摄入是公认的全氟和多氟化合物(per- and polyfluoroalkyl substances, PFAS)的人类主要暴露途径。猫类因为与人类共处一室而有着与人类相似的暴露途径,不过,它们有着不同于人类的膳食结构、体型和室内活动特征。我们分别于2008至2010年(n=21)和2012至2013年(n=22)采集了2组大于10岁的北加利福尼亚州猫(Northern California cats)的血清,并测定了血清中的PFAS浓度。第二阶段(2012–2013)总PFAS浓度(∑PFAS)的几何平均数(GM)为8.10 ng/mL低于第一阶段(2008–2010)的15.8 ng/mL,而两阶段的PFAS种类和组成相似。同时,我们也于2008–2010在相同地理区域采集了人类血清,并分析得到血清中的∑PFAS的GM为14.3 ng/mL。猫类血清中长链全氟羧酸(特别是PFNA和PFUnDA)的浓度显著高于人类血清中的。第二阶段采集的样品测定结果表明甲状腺机能亢进(hyperthyroid, HT)的猫类血清∑PFAS的GM(9.50 ng/mL)高于非HT的猫类(7.24 ng/mL)。其中HT猫类血清PFOA浓度显著增高(P<0.05)。研究表明PFAS浓度与猫类HT有可能的相关性,确切的结果需要进一步研究。 精选自Miaomiao Wang, Weihong Guo, Steve Gardner, Myrto Petreas,June‐Soo Park. Per- and Polyfluoroalkyl Substances in Northern California Cats: Temporal Comparison and a Possible Link to Cat Hyperthyroidism. Environmental Toxicology and Chemistry,2018,37:2523–2529.
详情请见 https://doi.org/10.1002/etc.4239
  
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Miaomiao Wang, Weihong Guo, Steve Gardner, Myrto Petreas, June‐Soo Park
英文摘要:
      The indoor environment and dietary intake are considered to be major human exposure pathways to per- and polyfluoroalkyl substances (PFAS). Cats have similar exposures to humans by sharing their residential environments, while they have different diet, body sizes and indoor activities. Here we report PFAS levels in the serum of two groups of Northern California cats (>10 years old) collected during two time periods: 2008-10 (n=21) and 2012-13 (n=22). Levels of ∑PFAS (GM, geometric mean) were lower in the second period (GM = 8.10 ng/mL) than the first time period (GM=15.8 ng/mL), while PFAS profiles remained similar. We also analyzed PFAS levels in human serum collected in the same time period (2008–2010) and geographic area, and compared the profiles and ∑PFAS levels (15.8 vs. 14.3 ng/mL for cat and human, respectively). Long chain perfluorinated carboxylic acids (PFCAs), especially PFNA and PFUnDA, were significantly higher in cat serum than in humans. Furthermore, serum from hyperthyroid (HT) cats in the second time period showed higher ∑PFAS level (9.50 ng/mL) compared to non-HT cats (7.24 ng/mL), and it is the PFOA levels that were statistically significantly higher in HT cats’ serum (p<0.05). This result may indicate a possible link between PFAS levels and cat HT, warranting a larger study for further investigation.
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