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吕银知1,2,张芊芊3,赵建亮3,*,姚理1,2,应光国3. 生理毒代动力学模型及其在有机污染物水生生态毒理研究中的应用[J]. 生态毒理学报, 2018, 13(5): 11-26
生理毒代动力学模型及其在有机污染物水生生态毒理研究中的应用
Physiologically Based Toxicokinetic Models and Application in Aquatic Ecotoxicological Studies of Organic Pollutants: A Review
投稿时间:2017-11-03  修订日期:2017-12-25
DOI:10.7524/AJE.1673-5897.20171103001
中文关键词:  有机污染物  水生生物  生理毒代动力学模型  生态毒理  
英文关键词:organic chemicals  aquatic organisms  ecotoxicology  PBTK model  fish
基金项目:国家自然科学基金项目(41877360, 41603105);广东省科技计划项目(2015B020235012)
作者单位
吕银知1,2,张芊芊3,赵建亮3,*,姚理1,2,应光国3 1. 中国科学院广州地球化学研究所 有机地球化学国家重点实验室广州 510640 2. 中国科学院大学北京 100049 3. 华南师范大学 环境研究院广州 510006 
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中文摘要:
      人类生产和生活使用各种人工合成的化学品,种类和数量急剧增长,对生态系统和人体健康造成了极大威胁。因此,亟需采用高效的方法对数量巨大的化合物进行毒性评价。对生理毒代动力学(PBTK)模型的建立过程及其在污染物生态毒理研究中的应用进行了综述。PBTK模型,又称生理药代动力学(PBPK)模型,是利用生理学和解剖学等原理,将生物体简化为用血流连接的肝、肾和脂肪等各组织器官房室,模拟化合物在生物体内的吸收、分布、代谢和排泄过程。模型参数包括生理参数和生化参数2个部分,可用MATLAB等软件进行模拟。模型已应用于数百余种有机污染物在鱼体等水生生物体的毒代动力学模拟。已有模拟结果能够预测化合物在生物体内的有效剂量,对化合物毒性进行评估,并可用于不同物种、不同剂量和不同暴露途径间的外推,有力推进了污染物生态毒理研究工作的开展。
  
AuthorAffiliation
Lv Yinzhi1,2, Zhang Qianqian3, Zhao Jianliang3,*, Yao Li1,2, Ying Guangguo31. State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 2. University of Chinese Academy of Sciences, Beijing 100049, China 3. Environmental Research Institute, South China Normal University, Guangzhou 510006, China
英文摘要:
      Many varieties of synthetic chemicals are used in our daily life and production activities. Synthetic chemicals are increasing rapidly in terms of class, number and amount. This could pose serious threats to the ecosystem and human health. Hence, it is urgent to develop an efficient evaluation approach to assess the toxicity for these chemicals, instead of using traditional toxicity test methods. In this context, we reviewed physiologically based toxicokinetic (PBTK) model and its application in aquatic ecotoxicological studies for organic chemicals. PBTK model, also known as physiologically based pharmacokinetic (PBPK) model, has gradually become a powerful tool for ecotoxicological study. Based on the knowledge of physiology and anatomy, the organisms are simplified as several compartments to represent various tissues and organs, which are connected with each other via blood flow; so that the absorption, distribution, metabolism and excretion (ADME) processes of compounds in organisms can be simulated using the PBTK model. The parameters in the PBTK model normally include physiological parameters and biochemical parameters, which can be applied in the simulation using MATLAB or other software. So far, the PBTK model has been widely applied to the simulation of several hundreds of organic chemicals in fish species and some other aquatic organisms. In literature, several hundreds of organic chemicals in fish have been simulated by the PBTK model. The modeling results displayed good prediction of the effective dose for organic pollutants in organisms, which is then applied to evaluate the toxicity effects of the compounds. The PBTK model can also be used for the extrapolations among different species, different doses and different exposure pathways. As a result, the application of PBTK model promoted and enhanced the research on the ecotoxicology of organic chemicals.
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