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宋雪薇1,马清萍1,于洋2,宋春磊3,林志芬3,张饮江1,*. 磺胺和四环素类抗生素对大肠杆菌联合突变效应的研究[J]. 生态毒理学报, 2018, 13(5): 110-117
磺胺和四环素类抗生素对大肠杆菌联合突变效应的研究
Combined Mutation Effect of Sulfonamide and Tetracycline Antibiotics Against Escherichia coli
投稿时间:2017-10-07  修订日期:2017-12-18
DOI:10.7524/AJE.1673-5897.20171007001
中文关键词:  磺胺  四环素  大肠杆菌  联合突变效应
英文关键词:sulfonamide  tetracycline  Escherichia coli  combined mutation effect
基金项目:同济大学污染控制与资源化研究国家重点实验室自主研究(重点)项目(PCRRK16007);国家自然科学面上基金(21377096,21577105,21777123);国家水体污染控制与治理重大专项(2018ZX07109-1);上海市科学技术委员会科研计划课题(14DZ2261100)和(17DZ1200103);环境化学与生态毒理学国家重点实验室开放基金课题(KF2016-11)
作者单位
宋雪薇1,马清萍1,于洋2,宋春磊3,林志芬3,张饮江1,* 1. 上海海洋大学海洋生态与环境学院上海 201306 2. 环境保护部固体废物与化学品管理技术中心北京 100029 3. 污染控制与资源化研究国家重点实验室同济大学环境科学与工程学院上海污染控制与生态安全研究院上海 200092 
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中文摘要:
      抗生素的滥用造成的环境安全问题已不可忽视,关于抗生素联合毒性效应研究较多,但联合突变效应研究较少。因此,本文以大肠杆菌为受试生物,研究了2种磺胺类抗生素(磺胺氯哒嗪(SCP)、磺胺二甲嘧啶(SMZ))和3种四环素类抗生素(二甲胺四环素(MH)、盐酸四环素(TH)和盐酸强力霉素(DH))单一及联合暴露时对大肠杆菌的突变效应。结果表明:在单一暴露下,磺胺类抗生素会促进大肠杆菌的突变效应,四环素类抗生素没有明显的促进作用;联合暴露下,磺胺类抗生素对大肠杆菌突变效应为相加,磺胺和四环素类抗生素对大肠杆菌突变效应为拮抗。本研究初步探索了抗生素对大肠杆菌的联合致突变风险,为今后环境中抗生素混合暴露的生态风险评价和抗生素污染控制标准制定提供一种理论支撑。
  
AuthorAffiliation
Song Xuewei1, Ma Qingping1, Yu Yang2, Song Chunlei3, Lin Zhifen3, Zhang Yinjiang1,*1. College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China 2. Solid Waste and Chemicals Management Center, Ministry of Environmental Protection, Beijing 100029, China 3. State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Shanghai Institute of Pollution Control and Ecological Security, Tongji University, Shanghai 200092, China
英文摘要:
      The abuse of antibiotics has caused a series of environmental problems, which should not be ignored. Many studies have been conducted to investigate the combined toxicity of antibiotics, but few of them have ever focused on the joint effects on the bacterial resistance mutation. The present research studied the individual and joint effects of two sulfonamide antibiotics, (sulfachlorpyridazine (SCP), sulfamethazine (SMZ)) and three tetracycline antibiotics (minocycline (MH), tetracycline hydrochloride (TH) and doxycycline hydrochloride (DH)) on the mutation of E. coli. The results showed that: upon the individual exposure, sulfonamide antibiotics could promote the mutation of E. coli, while the tetracycline antibiotics have no obvious promotion; upon the combined exposure, binary sulfonamide antibiotics presented additive joint effects, whilst the mixtures of sulfonamide and tetracycline presented antagonistic joint effects on the resistance mutation of E. coli. This study preliminarily explored the risk of joint exposure of antibiotics on the resistance mutation of E. coli, providing a theoretical support for the ecological risk assessment on the joint effects of antibiotics in the real environment and attributing to the formulation of pollutant control standards in the future.
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